Dmel\Doc

General Information
Symbol	Dmel\Doc	Species	D.melanogaster
Name	Doc element	FlyBase ID	FBte0000341
Feature type	natural transposable element	Created / Updated	2006-12-04/2006-12-04
Sequences & Components
Complete element (bp)	4725 (Kaminker et al., 2002) to 5kb
Terminal repeat (bp)
Reference sequence	transposon_sequence_set.embl.txt.gz
Component genes	Doc\gag Doc\RTase
Sequence Accessions
	DDBJ/EMBL/GenBank Z71134 Z32386 Z32283 X62679 X17551 S50810 AL031027 AL024454
Sequence Ontology (SO)
Transposon type	non_LTR_retrotransposon (Kaminker et al., 2002, ) transposable_element (Kaminker et al., 2002, )
Insertions & Copy Number
Copy number and comments	55 in euchromatin of Release 3 genome annotation, of which 30 are full length. (Kaminker et al., 2002) 40
Search for	All insertions of this transposon Insertions in the sequenced genome Insertions in other genomes
Target Site Duplication
Size (bp)	6-13
Orthologs
Curated drosophilid orthologs	Dmau\Doc Dhyd\Doc Dsim\Doc
Comments
	The Doc element is transcribed as a full-length 5kb transcript which encodes two open reading frames (ORFs). Doc\gag (ORF1) encodes an RNA-binding protein and Doc\RTase (ORF2) encodes a reverse transcriptase. The RNA is localised on the Drosophila oocyte cytoskeleton. (Zhao and Bownes, 1998) Correlations between the rate of transposition and TE copy number are determined for Doc and are found to be positive. (Nuzhdin et al., 1997) Changes introduced in the promoter regions of distinct LINEs allows transcriptional activators to stimulate cryptic Inr modules. The response of different promoter constructs to the same enhancer is significantly influenced by the number, position and type of core elements present. (Minchiotti and Di Nocera, 1997) Doc elements are located in both euchromatin and heterochromatin. (Terrinoni et al., 1997) F-element, I-element and Doc basal promoters share the same architecture and functional organisation. (Minchiotti et al., 1997) One of a class of genes with TATA-less promoters that have the conserved DPE sequence. (Burke and Kadonaga, 1996) Distinct cis-acting DNA elements, clustered in a 50bp long DNA region located at the 5' end of unit-length Doc copies, cooperate to control RNA initiation. Sequences located 200bp downstream from the 5' end inhibit expression in a position and orientation-dependent manner. Inhibition appears to be due to reduced translation rather that to impaired synthesis. (Contursi et al., 1995) The distribution of transposable elements within heterochromatin indicates that they are major structural components of the heterochromatin. (Pimpinelli et al., 1995) Ectopic recombination can occur between two Doc elements. (Lim and Simmons, 1994) The Doc retrotransposon has been found unstable in certain stocks. (Pasyukova and Nuzhdin, 1993) Closely related to I-element, F-element, G-element and jockey element. (O'Hare et al., 1991) There is no sequence homology between the ends of the Doc element. Different Doc elements are conserved at the 3' end (which terminates with a polyadenylation signal followed by a stretch of oligo-A), but may be truncated at the 5' end, suggesting a mechanism of transposition via an RNA intermediate. (Driver et al., 1989) Doc elements lie at both break points of the Antp^73b inversion; these elements lie in inverted orientation and the inversion probably resulted from recombination between them. (Schneuwly et al., 1987) First described as an insertion in the BXC region on a chromosome carrying the Ubx^bx-3 mutation, although it is not responsible for the mutant phenotype. (Bender et al., 1983)
Other Information
Etymology

External Crossreferences
Sequence Crossreferences
	DDBJ/EMBL/GenBank Z71134 Z32386 Z32283 X62679 X17551 S50810 AL031027 AL024454
Other Crossreferences

Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Doc (ffrench-Constant et al., 2006, Gunawardane et al., 2007, Mito et al., 2005, Smith, 2007, Brennecke et al., 2007, Lecuyer et al., 2007) doc (Fablet et al., 2007) DOC (Gunawardane et al., 2007) Docmel (Casacuberta and Pardue, 2003) EG:80H7.8 EG:121E7.1 TE Doc (Kearney et al., 2004)
Name Synonym	doc element (Mackay et al., 1994) Doc element
Secondary FlyBase IDs
	FBgn0000481 FBtp0011424
References ( 103 )

Generate a list of	All references relating to this natural transposable element ( 103 )

List References by type	Research paper ( 76 ) Supplementary material ( 1 ) Review ( 14 ) Abstract ( 8 ) FlyBase analysis ( 1 ) Letter ( 2 ) Computer file ( 1 )
Recent research papers ( 4 )
	Brennecke et al., 2007, Cell 128(6): 1089--1103 Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. [FBrf0200494] Lecuyer et al., 2007, Cell 131(1): 174--187 Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. [FBrf0200939] Smith, 2007, Science 316(5831): 1586--1591 [FBrf0202564] Kim et al., 2006, Gene Expression Patterns 6(5): 504--518 Characterization of big bang, a novel gene encoding for PDZ domain-containing proteins that are dynamically expressed throughout Drosophila development. [FBrf0193930] Show all research papers ...
Recent reviews ( 2 )
	Fablet et al., 2007, Gene 390(1-2): 84--91 The evolution of retrotransposon regulatory regions and its consequences on the Drosophila melanogaster and Homo sapiens host genomes. [FBrf0194872] ffrench-Constant et al., 2006, BioEssays 28(1): 6--8 Resistance and the jumping gene. [FBrf0189798] Show all reviews ...