Reference Report

Reference
Citation	Kotarski, M.A., Leonard, D.A., Bennett, S.A., Bishop, C.P., Wahn, S.D., Sedore, S.A., Shrader, M. (1998). The Drosophila gene asteroid encodes a novel protein and displays dosage-sensitive interactions with Star and Egfr. Genome 41(2): 295--302.
FlyBase ID	FBrf0102955
Type of publication	Research paper
Offprint Available	No
External Crossreferences
PubMed ID	9644838
PubMed Abstract	The asteroid gene of Drosophila was found to lie within 189 bp of Star. Asteroid cDNA clones were isolated and sequenced and a single putative open reading frame was identified that encodes a novel protein of 815 amino acids with a calculated molecular mass of 93 kilodaltons. Using cDNA probes, asteroid transcripts were localized to the proliferative tissues of embryos and to the mitotically active tissue anterior to the morphogenetic furrow in eye imaginal discs. Ribonuclease protection assays identified a mutation of asteroid that acts as a dominant enhancer of Star mutations and also enhances the Ellipse mutation, EgfrE1. Based on these data, a model for asteroid gene function in EGF receptor signaling is presented.
Biosis	1346729
Zoological record	13504002776
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Secondary IDs
Language of publication	English
Additional language(s) of abstract	French
ISBN
Place of publication
Published In
Abbreviation	Genome
Title	Genome
Authors
Volume range	29-
Year range	1987-
Page range
Publisher	National Research Council Canada
Place of publication	Ottawa
Language of publication	English
ISBN/ISSN	0831-2796
CODEN	GENOE3
Data from Reference
Aberrations (4)
	Df(2L)S3 Df(2L)ast2 Df(3R)by10 T(2;3)S^L
Alleles (13)
	Egfr^E1 Egfr^f1 Egfr^f2 S¹ S⁵⁴ S^L ast¹ ast^K6 ast^K6r6 rho^ve-1 ro¹ sim¹ spi¹
Genes (7)
	Egfr S ast rho ro sim spi
Insertions (1)
	P{}ast^K6