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Reference
Citation	Kolodkin, A.L., Pickup, A.T., Lin, D.M., Goodman, C.S., Banerjee, U. (1994). Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila. Development 120(7): 1731--1745.
FlyBase ID	FBrf0073598
Type of publication	Research paper
Offprint Available	Yes
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PubMed ID	7924981
PubMed Abstract	Loss-of-function mutations in Star impart a dominant rough eye phenotype and, when homozygous, are embryonic lethal with ventrolateral cuticular defects. We have cloned the Star gene and show that it encodes a novel protein with a putative transmembrane domain. Star transcript is expressed in a dynamic pattern in the embryo including in cells of the ventral midline. In the larval eye disc, Star is expressed first at the morphogenetic furrow, then in the developing R2, R5, and R8 cells as well as in the posterior clusters of the disc in additional R cells. Star interacts with Drosophila EGF receptor in the eye and mosaic analysis of Star in the larval eye disc reveals that homozygous Star patches contain no developing R cells. Taken together with the expression pattern at the morphogenetic furrow, these results demonstrate an early role for Star in photoreceptor development. Additionally, loss-of-function mutations in Star act as suppressors of R7 development in a sensitized genetic background involving the Son of sevenless (Sos) locus, and overexpression of Star enhances R7 development in this genetic background. Based on the genetic interactions with Sos, we suggest that Star also has a later role in photoreceptor development including the recruitment of the R7 cell through the sevenless pathway.
Biosis	97404802
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Language of publication	English
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Abbreviation	Development
Title	Development
Authors
Volume range	99-
Year range	1987-
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Place of publication	Cambridge
Language of publication	English
ISBN/ISSN	0950-1991
CODEN	DEVPED
Data from Reference
Aberrations (2)
	Df(2L)ast2 Df(3R)by10
Alleles (21)
	Ecol\lacZ^S-F126 Egfr^E1 Egfr^f6 Gap1^sxt-BJ61 S^104E S¹ S⁵⁴ S^F126 S^IIN S^hs.7 S^hs.8 S^hs.PK S^hs.sev Sos^JC2 Sos^x122 ast¹ ast⁴ ast^unspecified boss¹ l(2)47Aa¹ sev⁶
Constructs (2)
	P{hsp70-S} P{sE-Star}
Genes (10)
	Ecol\lacZ Egfr Gap1 Ras85D S Sos ast boss l(2)47Aa sev
Insertions (3)
	P{FZ}S^F126 P{hsp70-S}7 P{hsp70-S}l(2)47Aa¹