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Gene Dmel\frtz

General Information
Symbol	Dmel\frtz	Species	D. melanogaster
Name	fritz	Annotation symbol	CG17657
Feature type	protein_coding_gene	FlyBase ID	FBgn0086698
Created / Updated	2007-07-20/2007-07-20
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	22B1-22B1	Sequence location	2L:1,711,299..1,715,861 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene fritz is referred to in FlyBase by the symbol frtz (CG17657, FBgn0086698). It has the cytological map location 22B1. Its sequence location is 2L:1711299..1715861. Its molecular function is unknown. It is involved in the biological processes: imaginal disc-derived wing hair site selection; establishment of planar polarity. 13 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: adult segment; organ system; thoracic segment; adult; peripheral nervous system; nervous system; metatarsus; adult cuticle; adult mesothoracic segment; appendage segment. It has one annotated transcript and one annotated polypeptide.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 22B1-22B1   Limits computationally determined from genome sequence between P{PZ}l(2)0411104111 and P{lacW}CG17646k11021
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\frtz for information on other features
Comments on Gene Model
	Small transposon fragment at 3' end of gene; within 3'UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) frtz-RA FBtr0077911  NM_134770   3614   951
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein frtz-PA   FBpp0077577   106.1   951   8.42     NP_608614   AAF51346
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat-like (IPR011046) WD40 repeat (IPR001680)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141928   AE003585 AAF51346   AX093981   BI237832   BI606201   BT004832 AAO45188   CO267743   CO267771   CO291793   CO316340   CO317708   EC066649   EC068826   EC084657   EC210609   EC252502
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VQ36
Maps to
Does NOT map to
Identified with	RE34143 (Collier et al., 2005) RH72421 (BDGP Project Members, 2000-, Collier et al., 2005)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation frtz[3] 2L:1,713,714..1,713,714 comment=Site of nucleic acid difference inferred by FlyBase based on reported amino acid change evidence=experimental na_change=G1713714C pr_change=D375H|frtz-PA reported_na_change=G?C reported_pr_change=D375A (Collier et al., 2005) point mutation frtz[1]-1 2L:1,713,319..1,713,319 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. comment=Difference thought to be responsible for mutant phenotype. Other differences thought to be polymorphic variants. evidence=experimental na_change=T1713319A pr_change=Y506@|frtz-PA reported_na_change=T?A reported_pr_change=Y506@ (Collier et al., 2005) point mutation frtz[2] 2L:1,713,107..1,713,107 comment=Site of nucleic acid difference inferred by FlyBase based on reported amino acid change evidence=experimental na_change=A1713107T pr_change=K558@|frtz-PA reported_na_change=A?T reported_pr_change=K558@ (Collier et al., 2005) point mutation frtz[27]-1 2L:1,712,377..1,712,377 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=A1712377T pr_change=K783M|frtz-PA reported_na_change=A?T reported_pr_change=K783M (Collier et al., 2005) sequence variant frtz[1]-2 2L:1,713,213..1,713,213 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. comment=One of four amino acid substitutions reported for this allele. Difference thought to be polymorphic variant. evidence=experimental na_change=T6649A pr_change=D542N|frtz-PA reported_pr_change=D542N (Collier et al., 2005) sequence variant frtz[1]-3 2L:1,712,621..1,712,621 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of four amino acid substitutions reported for this allele. Difference thought to be polymorphic variant. evidence=experimental na_change=C7241A pr_change=P720T|frtz-PA reported_pr_change=P720T (Collier et al., 2005) sequence variant frtz[27]-2 2L:1,712,621..1,712,621 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of three amino acid substitutions reported for this allele. Difference thought to be polymorphic variant. evidence=experimental na_change=C7241A pr_change=P720T|frtz-PA reported_pr_change=P720T (Collier et al., 2005) sequence variant frtz[1]-4 2L:1,712,399..1,712,399 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of four amino acid substitutions reported for this allele. Difference thought to be polymorphic variant. evidence=experimental na_change=C7463A pr_change=P776T|frtz-PA reported_pr_change=P776T (Collier et al., 2005) sequence variant frtz[27]-3 2L:1,712,399..1,712,399 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. One of three amino acid substitutions reported for this allele. Difference thought to be polymorphic variant. evidence=experimental na_change=C7463A pr_change=P776T|frtz-PA reported_pr_change=P776T (Collier et al., 2005)
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable | reduced frtz7 Other Phenotypes Allele visible frtz1 frtzunspecified visible | cell autonomous | recessive | somatic clone frtz33 visible | recessive | conditional - cold sensitive frtz33 visible | conditional - heat sensitive frtz3 tissue polarity defective frtz1 frtzunspecified tissue polarity defective | cell autonomous | recessive | somatic clone frtz33 tissue polarity defective | recessive | conditional - cold sensitive frtz33 tissue polarity defective | conditional - heat sensitive frtz3 Sterility Allele fertile | reduced frtz7 Phenotype manifest in Allele triple row frtz1 wing hair | supernumerary frtz2 frtz33 wing hair | conditional - heat sensitive frtz3 wing hair | supernumerary | conditional - heat sensitive frtz3 macrochaeta frtz33 microchaeta frtz33 wing hair | conditional - cold sensitive frtz33 wing hair | cell autonomous | somatic clone | supernumerary frtz33 wing hair | cell autonomous | somatic clone frtz33 denticle row frtz33 leg frtzunspecified leg sensillum frtzunspecified joint | ectopic frtzunspecified bract frtzunspecified tarsal segment 3 frtzunspecified tarsal segment 4 frtzunspecified
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of frtz Class Mutagen Stocks Known lesion frtz1 ethyl methanesulfonate 2 -- frtz26 ethyl methanesulfonate 0 -- frtz27 X ray 0 -- frtz28 X ray 0 Yes frtz29 X ray 0 Yes frtz2 0 -- frtz30 X ray 0 Yes frtz33 X ray 0 Yes frtz3 hypomorph X ray 1 -- frtz7 X ray 0 Yes frtzKG08171 0 -- frtzunspecified 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of frtz Class Mutagen Stocks Known lesion frtzGD9437 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes
Aneuploid Aberrations
Useful deficiency	Df(2L)frtz14   Df(2L)frtz19
Useful duplication	Dp(2;2)M+Su24+-1
Disrupted in	Df(2L)Exel6005 (Ryder, 2004.4.26) Df(2L)F.1 (Collier et al., 2005) Df(2L)S2 (Collier et al., 2005) Df(2L)dp-79b (Collier et al., 2005) Df(2L)frtz11 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz14 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz17 (Roote, 1999.11.22) Df(2L)frtz19 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz24 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz25 (Roote, 1999.11.22, Collier et al., 2005) Df(2L)frtz7 (Collier et al., 2005)
Partially disrupted in	Df(2L)frtz7 (Collier et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9437} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}mRpL48f08082 NA P{SUPor-P}KG04255a NA P{SUPor-P}frtzKG08171 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 2 )
Molecular Function
CV term Evidence References
Biological Process
CV term Evidence References
establishment of planar polarity inferred from mutant phenotype (Collier et al., 2002)
imaginal disc-derived wing hair site selection inferred from mutant phenotype (Collier et al., 2005)
Cellular Component
CV term Evidence References
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions frtz allele Gene References frtz3 in (Collier et al., 2005) fy (Collier et al., 2005) unspecified sha (Ren et al., 2006)
External Data
Linkouts
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\GA14599
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Kyoto	108248 frtz1 bw1
Bloomington	5455 frtz1 bw1 5456 frtz3 P{neoFRT}42D cn1/CyO 14939 y1; P{SUPor-P}KG08171/CyO; ry506
Harvard	- PBac{WH}mRpL48f08082
VDRC	v40088 w1118; P{GD9437}v40088
Genomic Clones ( 1 )
	BACR19B15
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE34143
Other clones	EK198307 EK151814 EK151645 EK264601 EK268838
RNAi & Array Information
Affy Oligo
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG17657 anon-WO0118547.105 Source for merge of CG17657 anon-WO0118547.105 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of: frtz CG17657 (Collier et al., 2005)
Additional comments
Comments About Role
	A tissue polarity gene. (Collier et al., 1997) frtz is a planar cell polarity (PCP) effector gene that functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites. (Collier et al., 2005)
Comments About Molecular Function
Other Comments
	Area matching Drosophila EST AA141928. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134770 RefSeq (Proteins) • NP_608614 DDBJ / EMBL / GenBank • BT004832 BI606201 AX093981 AE003585 AA141928 AAO45188 AAF51346 UniProtKB/TrEMBL • Q9VQ36
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40 repeat-like (IPR011046) WD40 repeat (IPR001680)
Linkouts
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	anon-WO0118547.105   CG17657 (Collier et al., 2005, Stark et al., 2003, Giot et al., 2003, FlyBase, 1996-, Davies et al., 2001) fritz (Ren et al., 2006) frtz
Name Synonym	fritz (Chanut-Delalande et al., 2006, Collier et al., 1997, Yan et al., 2007, Mihaly et al., 2007, )
Secondary FlyBase IDs
	FBgn0031358 FBgn0020302 FBgn0062241
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 1 ) Review  ( 4 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 8 ) FlyBase analysis  ( 3 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Chanut-Delalande et al., 2006, PLoS Biol. 4(9): Shavenbaby couples patterning to epidermal cell shape control. [FBrf0191902] Ren et al., 2006, Genetics 172(3): 1643--1653 The shavenoid gene of Drosophila encodes a novel actin cytoskeleton interacting protein that promotes wing hair morphogenesis. [FBrf0190766] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...