Gene Dmel\Doc\gag

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General Information

Symbol

Dmel\Doc\gag

Species

D. melanogaster

Name

gag

Annotation symbol

Feature type

transposable_element_gene

FlyBase ID

FBgn0024789

Created / Updated

2006-08-20/2007-09-12

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene gag is referred to in FlyBase by the symbol Doc\gag (FBgn0024789). It has not been localized to the genome sequence. Its molecular function is described as: zinc ion binding; nucleic acid binding. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has no annotated transcripts.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, CCHC-type (IPR001878)

Pre-C2HC (IPR006579)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q04134

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0024789

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Doc\gag	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Doc\gag	Class	Mutagen	Stocks	Known lesion
Doc\gag^{arm.T:Avic\GFP-EGFP}		in vitro construct \| regulatory fusion in vitro construct \| coding region fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 2 )

Molecular Function

CV term

Evidence

References

nucleic acid binding

inferred from electronic annotation with InterPro:IPR001878

(FlyBase Curators et al., 2004-)

zinc ion binding

inferred from electronic annotation with InterPro:IPR001878

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

transposable_element_gene

(Zhao and Bownes, 1998)

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Doc\gag allele

Gene

References

External Data

Linkouts

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Dsim\Doc\gag

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Encoded by

Doc

Additional comments

Comments About Role

The Doc element is transcribed as a full-length 5kb transcript which encodes two open reading frames (ORFs). Doc\gag (ORF1) encodes an RNA-binding protein and Doc\RTase (ORF2) encodes a reverse transcriptase. The RNA is localised on the Drosophila oocyte cytoskeleton.

(Zhao and Bownes, 1998)

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Q04134

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, CCHC-type (IPR001878)

Pre-C2HC (IPR006579)

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0024789

Synonyms & Secondary IDs ( 4 )

Reported As

Symbol Synonym

Doc\gag

Doc ORF1

(Rashkova et al., 2002)

ORF1

(Zhao and Bownes, 1998)

Name Synonym

gag

Secondary FlyBase IDs

References ( 4 )

Research paper

Rashkova et al., 2002, Proc. Natl. Acad. Sci. USA 99(6): 3621--3626: Element-specific localization of Drosophila retrotransposon Gag proteins occurs in both nucleus and cytoplasm. [FBrf0147186]
Zhao and Bownes, 1998, Molec. gen. Genet. 257(5): 497--504: The RNA product of the Doc retrotransposon is localized on the Drosophila oocyte cytoskeleton. [FBrf0102424]

Review

Pardue and DeBaryshe, 2003, A. Rev. Genet. 37: 485--511: Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres. [FBrf0167268]

Personal communication to FlyBase

FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]