Gene Dmel\ast

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General Information

Symbol

Dmel\ast

Species

D. melanogaster

Name

asteroid

Annotation symbol

CG4426

Feature type

protein_coding_gene

FlyBase ID

FBgn0015905

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

21E4-21E4

Sequence location

2L:1,077,980..1,080,809 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene asteroid is referred to in FlyBase by the symbol ast (CG4426, FBgn0015905). It has the cytological map location 21E4. Its sequence location is 2L:1077980..1080809. Its molecular function is unknown. It is involved in the biological processes: compound eye morphogenesis; imaginal disc-derived wing vein morphogenesis; epidermal growth factor receptor signaling pathway; larval somatic muscle development; compound eye photoreceptor fate commitment; imaginal disc-derived wing morphogenesis. 34 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: adult segment; adult mesothoracic segment; organ system; thoracic segment; adult; anatomical structure; peripheral nervous system; wing blade; nervous system; embryonic/larval hypodermal muscle. It has one annotated transcript and one annotated polypeptide.

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

ast: asteroid

Eyes small and rough. Veins L2, L3, L4, and L5 do not always extend to margin. Overlaps wild type rarely. S +/+ ast has very small eyes with fused facets; veins L2 to L5 incomplete at tip. S ast/+ ast has slightly larger eye than S +/+ ast. S ast/+ + resembles S +/+ +. S +/+ ast and ast/ast partially suppress px and net. Eyes of ast/E(S) rough. RK2.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21E4-21E4

Limits computationally determined from genome sequence between P{lacW}l(2)k09610^k09610&P{lacW}S^k09538a and P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

21E1-21E2

(Kotarski, 1998.2.5)

21E2-21E2

(determined by in situ hybridisation)

(Higson et al., 1993)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

(Lewis, 1942, Lewis, 1945, Lewis, 1951)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Overall orientation not stated: S- ast+

(Kotarski et al., 1998)

Gene Model & Products

Please see the GBrowse view of Dmel\ast for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

ast-RA

FBtr0077952

NM_078727

2719

854

Additional Transcript Data & Comments

Reported size (kB)

2.9 (northern blot)

(Kotarski et al., 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

ast-PA

FBpp0077617

98.4

854

6.02

NP_523451

AAF51424

Additional Polypeptide Data & Comments

Reported size (kD)

815 (aa); 93.5 (kD predicted)

(Kotarski et al., 1998)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0015905

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

No name available (IPR000513)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VPW1

Maps to

Does NOT map to

Identified with

SD02572

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

5752

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

embryonic stage

(Kotarski et al., 1998)

larval stage | third instar

morphogenetic furrow | anterior to

(Kotarski et al., 1998)

embryonic stage-adult stage

(Kotarski et al., 1998)

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI531506

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0015905

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0015905

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0015905

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

lethal | recessive

Other Phenotypes

Allele

wild-type

ast^rv1

wild-type (with T(2;4)ast^v)

ast^rv1

wild-type (with ast¹)

ast^rv1

wild-type (with ast³)

ast^rv1

wild-type (with ast⁴)

ast^rv1

wild-type (with ast^rv1)

wild-type (with ast^rv2)

ast^rv1

visible (with ast¹)

visible (with ast^K9)

ast¹

visible (with ast^K7)

ast¹

visible (with ast^K6)

ast¹

visible (with ast^K5)

ast¹

visible (with ast^K3)

ast¹

visible (with ast^K2)

ast¹

visible (with ast^K21)

ast¹

visible (with ast^K20)

ast¹

visible (with ast^K19)

ast¹

visible (with ast^K18)

ast¹

visible (with ast^K17)

ast¹

visible (with ast^K16)

ast¹

visible (with ast^K15)

ast¹

visible (with ast^K14)

ast¹

visible (with ast^K13)

ast¹

visible (with ast^K12)

ast¹

visible (with ast^K11)

ast¹

visible (with ast^B612)

ast¹

visible | recessive

visible | dominant

ast^KG07563

visible | partially | recessive

ast¹

Sterility

Allele

female sterile | recessive

ast²

Phenotype manifest in

Allele

ommatidium (with ast^K19)

ast¹

wing vein L2 (with ast^K19)

ast¹

wing vein L3 (with ast^K19)

ast¹

wing vein L4 (with ast^K19)

ast¹

wing vein L5 (with ast^K19)

ast¹

ommatidium (with ast^K6)

ast¹

ommatidium (with ast^K18)

ast¹

wing vein L2 (with ast^K18)

ast¹

wing vein L3 (with ast^K18)

ast¹

wing vein L4 (with ast^K18)

ast¹

wing vein L5 (with ast^K18)

ast¹

ommatidium (with ast^K7)

ast¹

wing vein L2 (with ast^K7)

ast¹

wing vein L3 (with ast^K7)

ast¹

wing vein L4 (with ast^K7)

ast¹

wing vein L5 (with ast^K7)

ast¹

ommatidium (with ast^K20)

ast¹

ommatidium (with ast^K9)

ast¹

wing vein L2 (with ast^K9)

ast¹

wing vein L3 (with ast^K9)

ast¹

wing vein L4 (with ast^K9)

ast¹

wing vein L5 (with ast^K9)

ast¹

ommatidium (with ast^B612)

ast¹

wing vein L2 (with ast^B612)

ast¹

wing vein L3 (with ast^B612)

ast¹

wing vein L4 (with ast^B612)

ast¹

wing vein L5 (with ast^B612)

ast¹

ommatidium (with ast^K12)

ast¹

wing vein L2 (with ast^K12)

ast¹

wing vein L3 (with ast^K12)

ast¹

wing vein L4 (with ast^K12)

ast¹

wing vein L5 (with ast^K12)

ast¹

ommatidium (with ast^K3)

ast¹

wing vein L2 (with ast^K3)

ast¹

wing vein L3 (with ast^K3)

ast¹

wing vein L4 (with ast^K3)

ast¹

wing vein L5 (with ast^K3)

ast¹

ommatidium (with ast^K11)

ast¹

ommatidium (with ast^K2)

ast¹

wing vein L2 (with ast^K2)

ast¹

wing vein L3 (with ast^K2)

ast¹

wing vein L4 (with ast^K2)

ast¹

wing vein L5 (with ast^K2)

ast¹

ommatidium (with ast^K5)

ast¹

wing vein L2 (with ast^K5)

ast¹

wing vein L3 (with ast^K5)

ast¹

wing vein L4 (with ast^K5)

ast¹

wing vein L5 (with ast^K5)

ast¹

ommatidium (with ast^K14)

ast¹

wing vein L2 (with ast^K14)

ast¹

wing vein L3 (with ast^K14)

ast¹

wing vein L4 (with ast^K14)

ast¹

wing vein L5 (with ast^K14)

ast¹

ommatidium (with ast^K15)

ast¹

wing vein L2 (with ast^K15)

ast¹

wing vein L3 (with ast^K15)

ast¹

wing vein L4 (with ast^K15)

ast¹

wing vein L5 (with ast^K15)

ast¹

ommatidium (with ast^K16)

ast¹

wing vein L2 (with ast^K16)

ast¹

wing vein L3 (with ast^K16)

ast¹

wing vein L4 (with ast^K16)

ast¹

wing vein L5 (with ast^K16)

ast¹

ommatidium (with ast^K17)

ast¹

wing vein L2 (with ast^K17)

ast¹

wing vein L3 (with ast^K17)

ast¹

wing vein L4 (with ast^K17)

ast¹

wing vein L5 (with ast^K17)

ast¹

ommatidium (with ast^K21)

ast¹

wing vein L2 (with ast^K21)

ast¹

wing vein L3 (with ast^K21)

ast¹

wing vein L4 (with ast^K21)

ast¹

wing vein L5 (with ast^K21)

ast¹

ommatidium (with ast^K13)

ast¹

wing vein L2 (with ast^K13)

ast¹

wing vein L3 (with ast^K13)

ast¹

wing vein L4 (with ast^K13)

ast¹

wing vein L5 (with ast^K13)

ast¹

wing vein

ast¹

eye

ommatidium

wing vein L2

ast¹

wing vein L3

ast¹

wing vein L4

ast¹

wing vein L5

ast¹

embryonic somatic muscle (with Df(2L)ast4)

ast¹

abdominal lateral longitudinal muscle 1 (with Df(2L)ast4)

ast¹

abdominal dorsal oblique muscle 4 (with Df(2L)ast4)

ast¹

ommatidium (with ast¹)

wing vein L2 (with ast¹)

wing vein L3 (with ast¹)

wing vein L4 (with ast¹)

wing vein L5 (with ast¹)

wing vein | ectopic

ast^KG07563

wing

ast^KG07563

Classical Alleles ( 33 )

For All Classical Alleles Show

Allele of ast	Class	Mutagen	Stocks	Known lesion
ast¹		spontaneous	18	Yes
ast²		spontaneous	0	--
ast³		spontaneous	2	--
ast⁴		spontaneous	4	--
ast⁵		spontaneous	0	--
ast^B612	hypomorph	Δ2-3	0	Yes
ast^K11	hypomorph	Δ2-3	0	--
ast^K12	hypomorph	Δ2-3	0	Yes
ast^K13	hypomorph	Δ2-3	0	--
ast^K14	hypomorph	Δ2-3	0	--
ast^K15	hypomorph	Δ2-3	0	--
ast^K16	hypomorph	Δ2-3	0	--
ast^K17	hypomorph	Δ2-3	0	--
ast^K18	hypomorph	Δ2-3	0	--
ast^K19	hypomorph	Δ2-3	0	--
ast^K20	hypomorph	Δ2-3	0	Yes
ast^K21	hypomorph	Δ2-3	0	--
ast^K2	hypomorph	Δ2-3	0	--
ast^K3	hypomorph	Δ2-3	0	Yes
ast^K5	hypomorph	Δ2-3	0	--
ast^K6	hypomorph	Δ2-3	0	Yes
ast^K6e3		Δ2-3	0	--
ast^K6r6		Δ2-3	0	Yes
ast^K6r7		Δ2-3	0	--
ast^K7	hypomorph	Δ2-3	0	--
ast^K9	hypomorph	Δ2-3	0	Yes
ast^KG07563			1	--
ast^R1		γ ray	0	--
ast^X		X ray	4	--
ast^rv1		X ray	0	--
ast^rv2		X ray	0	--
ast^rv3		X ray	0	--
ast^unspecified			0	--