A Database of Drosophila Genes & Genomes

 

Gene Dmel\MstProx

General Information
SymbolDmel\MstProxSpeciesD. melanogaster
NameMstProxAnnotation symbolCG1149
Feature typeprotein_coding_geneFlyBase IDFBgn0015770
Created / Updated2005-01-10/2005-01-10
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map 84D5-84D5 Sequence location3R:3,191,661..3,195,027 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol MstProx (CG1149, FBgn0015770). It has the cytological map location 84D5. Its sequence location is 3R:3191661..3195027. Its molecular function is described as: transmembrane receptor activity; growth factor activity. It is involved in the biological processes: defense response; signal transduction; innate immune response. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
84D5-84D5  
Limits computationally determined from genome sequence between P{EP}EP3060EP3060 and P{PZ}grn05930  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
84D3-84D4
 
(Tauszig, 2000.3.23)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: MstProx+ Mst84Da-
(Schaefer, 1998.1.22)
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\MstProx for information on other features
detailed view FBtr0112841 FBtr0081587 FBtr0081586 FBtr0081584 FBtr0081585 FBpp0081106 FBpp0111754 FBpp0081105 FBpp0081103 FBpp0081104 FBti0025110
Comments on Gene Model
Replace with wild type sequence from GenBank accession U42425
Probable mutation in sequenced strain:premature stop. C to T mutation at base 1001 of exon 2 (CGA to TGA; accession-U42425).
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
MstProx-RA
FBtr0081585
 NM_141462
  3262
  965
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
MstProx-PA  
FBpp0081104  
112.5  
965  
8.41  
  NP_649719
  AAF54021
Additional Polypeptide Data & Comments
Reported size (kD)
711 (aa)
(Mitcham et al., 1996)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Toll-Interleukin receptor (IPR000157)
Leucine-rich repeat, cysteine-rich flanking region, N-terminal (IPR000372)
Leucine-rich repeat (IPR001611)
Transforming growth factor beta (IPR001839)
Interleukin-1 receptor, type I/Toll precursor (IPR004075)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AC008226
 
AE003672
AAF54021
 
AF247769
AAF86229
 
BE978813
 
CO265465
 
EC244648
 
U42425
AAC46999
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    (FlyBase, 1992-)
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 1 )
        For All Classical Alleles Show

        Allele of MstProxClassMutagenStocksKnown lesion
        MstProx1
          		2 --
          hide Alleles Carried on Transgenic Constructs ( 1 )
          For All Alleles Carried on Transgenic Constructs Show

          Allele of MstProxClassMutagenStocksKnown lesion
          MstProxGD73132 Yes
          hide Aneuploid Aberrations
          Useful deficiency
           
          Useful duplication
           
          Disrupted in
          (Ryder, 2004.4.26)
          hide Transgenic Constructs & Insertions
          Transgenic Constructs
          Type of construct
          Name
          Expression data
          UAS construct
          P{GD13650}
          NA
          P{GD7313}
          NA
          Insertions
          Type of insertions
          Name
          Expression data
          hide Related Comments
          Please look at the allele reports for the complete phenotype data
          hide Gene Ontology: Function, Process & Cellular Component ( 8 )
          hide Molecular Function
          CV term
          Evidence
          References
          growth factor activity
          inferred from electronic annotation with InterPro:IPR001839
          (FlyBase Curators et al., 2004-)
          transmembrane receptor activity
          non-traceable author statement
          (Tauszig, 2000.3.23)
          inferred from sequence or structural similarity
          (Lemaitre, 2000.12.20)
          inferred from electronic annotation with InterPro:IPR000157, InterPro:IPR004075
          (FlyBase Curators et al., 2004-)
          hide Biological Process
          CV term
          Evidence
          References
          defense response
          non-traceable author statement
          (Lemaitre, 2000.12.20)
          innate immune response
          inferred from electronic annotation with InterPro:IPR000157, InterPro:IPR004075
          (FlyBase Curators et al., 2004-)
          signal transduction
          inferred from sequence or structural similarity
          (Lemaitre, 2000.12.20)
          inferred from electronic annotation with InterPro:IPR000157, InterPro:IPR004075
          (FlyBase Curators et al., 2004-)
          hide Cellular Component
          CV term
          Evidence
          References
          integral to membrane
          inferred from sequence or structural similarity
          (Lemaitre, 2000.12.20)
          intrinsic to membrane
          inferred from electronic annotation with InterPro:IPR000157, InterPro:IPR004075
          (FlyBase Curators et al., 2004-)
          plasma membrane
          non-traceable author statement
          (Tauszig, 2000.3.23)
          non-traceable author statement
          (Sims, 1995.12.6)
          hide Sequence Ontology: Class of Gene
          protein_coding_gene
           
          nuclear_gene
           
          hide Interactions & Pathways
          hide Summary of Genetic Interactions
          Interacts with
          Please look at the allele data for full details of the genetic interactions
          MstProx allele
          Gene
          References
          hide External Data
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          hide Orthologs
          Genome-wide drosophilid orthologs
          Curated drosophilid orthologs
          Linkouts
          hide Functional Complementation between Species
          hide Inter-Species Misexpression Data
          Produces phenotype in
          Produces NO phenotype in
          hide Stocks & Reagents
          hide Stocks Listed in FlyBase ( 4 )
          VDRC
          v31511
          w1118; P{GD7313}v31511/CyO
          v31513
          w1118; P{GD7313}v31513/CyO
          Tucson
          14021-0231.36
          y1 ocR3.2; Gr22b1 Gr22d1 cn1 CG33964R4.2 bw1 sp1; LysC1 labR4.2 MstProx1 GstD51 Rh61 <E>
          Bloomington
          2057
          y1 ocR3.2; Gr22b1 Gr22d1 cn1 CG33964R4.2 bw1 sp1; LysC1 labR4.2 MstProx1 GstD51 Rh61 <E>
          hide Genomic Clones ( 2 )
          hide cDNA Clones ( 2 )
          cDNA Clones, Fully Sequenced
          BDGP DGC clones
          Other clones
          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          hide RNAi & Array Information
          Affy Oligo
          Linkouts
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
          •
          hide Antibody Information
          hide Other Information
          hide Discoverer
          hide Etymology
          hide Identification
          hide Position Effect Variegation Data
          hide Relationship to Other Genes
          Source for database identity of
          Source for identity of: MstProx CG1149
          (Milshina, 1999.11)
          Source for identity of: MstProx Toll-3 Source for identity of MstProx Toll-3 was sequence comparison (date:000721).
          (FlyBase, 1996-)
          Source for database merge of
          Additional comments
          hide Comments About Role
          Encodes an interleukin-1 receptor-type protein.
          (Mitcham et al., 1996)
          hide Comments About Molecular Function
          hide Other Comments
          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
          (Kiger et al., 2003)
          hide External Crossreferences & Linkouts
          Sequence Crossreferences
          RefSeq (Transcripts)
          •
          RefSeq (Proteins)
          •
          DDBJ / EMBL / GenBank
          •
          UniProtKB/TrEMBL
          •
          Other Crossreferences
          InterPro domains - A database of protein families, domains, and functional sites
          •
          Toll-Interleukin receptor (IPR000157)
          Leucine-rich repeat, cysteine-rich flanking region, N-terminal (IPR000372)
          Leucine-rich repeat (IPR001611)
          Transforming growth factor beta (IPR001839)
          Interleukin-1 receptor, type I/Toll precursor (IPR004075)
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          •
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          •
          FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
          •
          GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
          •
          GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
          •
          hide Synonyms & Secondary IDs ( 9 )
          Reported As
          Symbol Synonym
          CG1149
          (Imler, 2000.10.17, )
          DmMstProx
           
          dTLR3
          (Silverman and Maniatis, 2001)
          dToll3
          (Singh et al., 2003)
          mstprox
          (Lemaitre, 2000.12.20)
          MstProx
           
          Tl-3
          (Lemaitre, 2000.12.20, Khush and Lemaitre, 2000)
          toll
          (Janssens and Beyaert, 2002)
          Toll-3
          (Lavine and Strand, 2002, Kimbrell and Beutler, 2001, Imler and Hoffmann, 2001, Kambris et al., 2002, Imler, 2000.10.17, Wasserman, 2000, Tauszig et al., 2000, Tauszig, 2000.3.23)
          Name Synonym
          MstProx
           
          Secondary FlyBase IDs
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