Gene Dmel\GstS1

General Information
Symbol	Dmel\GstS1	Species	D. melanogaster
Name	Glutathione S transferase S1	Annotation symbol	CG8938
Feature type	protein_coding_gene	FlyBase ID	FBgn0010226
Created / Updated	2005-01-10/2005-01-10
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	53F7-53F8	Sequence location	2R:12,980,758..12,984,935 [-]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene Glutathione S transferase S1 is referred to in FlyBase by the symbol GstS1 (CG8938, FBgn0010226). It has the cytological map location 53F7-53F8. Its sequence location is 2R:12980758..12984935. Its molecular function is described as: glutathione transferase activity; glutathione peroxidase activity. It is involved in the biological process response to oxidative stress. 23 alleles are reported. The phenotypes of these alleles are annotated with: wing; eye; macrochaeta. It has 3 annotated transcripts and 3 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 53F7-53F8 Limits computationally determined from genome sequence between P{lacW}l(2)k11405^k11405&P{EP}EP641 and P{lacW}l(2)k10815^k10815
Experimentally Determined Cytological Location
Cytogenetic map Notes References 53F-53F (Beall, 1993.1.20) 53F1-53F5 (determined by in situ hybridisation) (Spradling et al., 1999) 53F4-53F5 (determined by in situ hybridisation) (BDGP Project Members, 1994-1999) 53F-53F (determined by in situ hybridisation) (Beall et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\GstS1 for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) GstS1-RA FBtr0087006 NM_166216 1757 249 GstS1-RB FBtr0087005 NM_079043 1786 249 GstS1-RC FBtr0100258 NM_166217 1419 249
Additional Transcript Data & Comments
Reported size (kB)	1.9, 1.6 (northern blot) (Beall et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein GstS1-PA FBpp0086157 27.6 249 4.29 NP_725653 AAF57901 GstS1-PB FBpp0086156 27.6 249 4.29 NP_523767 AAF57900 GstS1-PC FBpp0099646 27.6 249 4.29 NP_725654 AAM68496
Additional Polypeptide Data & Comments
Reported size (kD)	247 (aa) (Beall et al., 1992)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0010226
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glutathione S-transferase, N-terminal (IPR004045) Glutathione S-transferase, C-terminal (IPR004046) Glutathione S-transferase, C-terminal-like (IPR010987) Thioredoxin-like fold (IPR012336) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1M0U
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202360 AA246200 AA246244 AA246694 AA392169 AA439718 AA567208 AA735338 AA942452 AA949666 AA951750 AE003804 AAF57900 AE003804 AAF57901 AI257420 AI386582 AI455098 AI511685 AI514192 AI514193 AI516767 AI518506 AI944849 AI945311 AI946067 AI946526 AI946586 AQ024976 AQ025024 AQ025624 AQ025648 AQ025868 AQ025892 AQ025976 AQ026453 AQ073410 AY118328 AAM48357 BE975096 BE975194 BE975407 BE976720 BE976863 BE978379 BE978944 BF486191 BF486544 BF488123 BF488555 BF489717 BF490005 BF490380 BF491420 BF494054 BF495362 BF497862 BF500115 BF500278 BF502129 BF503688 BF504238 BF504455 BG631925 BG635312 BI163466 BI163530 BI164518 BI167017 BI168145 BI169332 BI170324 BI173900 BI214260 BI215475 BI216905 BI228079 BI229340 BI229751 BI231260 BI233192 BI237169 BI238142 BI240505 BI240969 BI352249 BI356330 BI363373 BI364486 BI364955 BI481555 BI483979 BI484656 BI486720 BI573897 BI573898 BI578682 BI580412 BI605672 BI611530 BI613411 BI623826 BI629876 BI634180 CA804640 CL705933 CO181857 CO182497 CO184276 CO184480 CO185908 CO187809 CO193207 CO266122 CO272709 CO276211 CO282866 CO283873 CO283908 CO296322 CO305353 CO323992 CO336054 CZ468887 CZ469187 CZ474140 CZ475852 CZ475853 CZ486897 EC052304 EC054850 EC055827 EC059493 EC060269 EC071883 EC083301 EC090504 EC195183 EC200617 EC201855 EC232923 EC240620 EC247597 EC252186 EC267755 ES691604 M95198 AAA28596 RH09366

UniProtKB/Swiss-Prot	P41043
UniProtKB/TrEMBL

Maps to
Does NOT map to
Identified with	bs28b04 bs20d11 bs11d01 bs27d09 bs06b08 LD26681 LD38044 LD42819 LP05778 (Oliver, 2001.8.16) LD14356 (Spradling et al., 1999) LD21131 (BDGP Project Members, 2000-, Oliver, 2001.8.16, Whitworth et al., 2005)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 12168
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference embryonic stage-adult stage (Beall et al., 1992)
Marker for

Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for

Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010226 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0010226 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0010226 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for GstS1 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for GstS1 Stage(s) 4-6 Stage(s) 7-8 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable GstS1^CB05261 GstS1^EY07338 GstS1^M26 semi-viable \| recessive GstS1^GS2160 lethal \| recessive GstS1⁰⁴²²⁷ GstS1^k08805 lethal, with Scer\GAL4^c355 GstS1^GS2160 Other Phenotypes Allele wild-type, with Scer\GAL4^dpp.blk1 GstS1^GS2160 visible, with Scer\GAL4^hs.2sev GstS1^GS2160 visible, with Scer\GAL4^29BD GstS1^GS2160 Sterility Allele