A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\LysE

General Information
SymbolDmel\LysESpeciesD. melanogaster
NameLysozyme EAnnotation symbolCG1180
Feature typeprotein_coding_geneFlyBase IDFBgn0004428
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)3LRecombination map
Cytogenetic map61F3-61F3Sequence location3L:1,212,924..1,213,413 [+]
Map ( GBrowse ) detailed view
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Automatically generated summary

See sections below for more information
The gene Lysozyme E is referred to in FlyBase by the symbol LysE (CG1180, FBgn0004428). It has the cytological map location 61F3. Its sequence location is 3L:1212924..1213413. Its molecular function is described as lysozyme activity. It is involved in the biological processes: antimicrobial humoral response; cell wall catabolic process. No alleles are reported. It has one annotated transcript and one annotated polypeptide.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
61F3-61F3  
Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
Overall orientation not stated: LysB+ LysC+ LysD- LysE+ LysP- LysS+
(Daffre et al., 1994)
hide Gene Model & Products
Please see the GBrowse view of Dmel\LysE for information on other features
detailed view FBtr0072629 FBtr0072634 FBtr0072630 FBpp0072530 FBpp0072526 FBti0075680 FBti0065612
Comments on Gene Model
DGC clone LP07339 appears problematic: incomplete CDS
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
LysE-RA
FBtr0072630
 NM_057479
  490
  140
Additional Transcript Data & Comments
Reported size (kB)
0.486 (longest cDNA)
(Daffre et al., 1994)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
LysE-PA  
FBpp0072526  
15.6  
140  
6.72  
  NP_476827
  AAF47451
Additional Polypeptide Data & Comments
Reported size (kD)
140 (aa)
(Daffre et al., 1994)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Glycoside hydrolase, family 22, lysozyme (IPR000974)
Glycoside hydrolase, family 22 (IPR001916)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AC004489
 
AC005847
 
AE003470
AAF47451
 
AI294047
 
AY119059
AAM50919
 
CO194958
 
Z22227
CAA80229
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Maps to
(FlyBase, 1992-)
Does NOT map to
Identified with
(BDGP Project Members, 2000-)
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Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
DEDB - Drosophila exon database: splicing graphs
•
Crossreferences
hide Expression Data
FlyBase-Curated Data
Transcript and
Protein data 		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
hide Summary of Transcript Expression
Stage
Tissue/Position
Reference
 larval stage,adult stage
 
(Daffre et al., 1994)
 adult stage
 adult midgut
(Daffre et al., 1994)
 larval stage
 embryonic/larval midgut
(Daffre et al., 1994)
Marker for
    Subcellular Localization
    CV Term
    hide Summary of Polypeptide Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide External Data & Images
      Linkouts
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      •
      GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
      •
      hide Alleles & Phenotypes
      hide Summary of Allele Phenotypes
      Phenotype manifest in
      Allele
      hide Classical Alleles ( 0 )
      For All Classical Alleles Show

      Allele of LysEClassMutagenStocksKnown lesion
      hide Alleles Carried on Transgenic Constructs ( 0 )
      For All Alleles Carried on Transgenic Constructs Show

      Allele of LysEClassMutagenStocksKnown lesion
      hide Aneuploid Aberrations
      Useful deficiency
       
      hide Transgenic Constructs & Insertions
      Transgenic Constructs
      Type of construct
      Name
      Expression data
      UAS construct
      P{GD5895}
      NA
      Insertions
      Type of insertions
      Name
      Expression data
      hide Related Comments
      Please look at the allele reports for the complete phenotype data
      Lysozymes are expressed at a high level mainly in the digestive tract, they are not a component of the haemolymph. Lysozyme is not induced by bacteria so is not part of the inducible immune response but instead has been recruited for digestion of symbiotic bacteria in the stomach.
      (Daffre et al., 1994)
      hide Gene Ontology: Function, Process & Cellular Component ( 4 )
      hide Molecular Function
      CV term
      Evidence
      References
      lysozyme activity
      inferred from sequence or structural similarity
      (Daffre et al., 1994)
      non-traceable author statement
      (Lemaitre, 2000.12.20)
      non-traceable author statement
      (Swiss-Prot Project Members, 1994.10.1)
      inferred from electronic annotation with InterPro:IPR000974
      (FlyBase Curators et al., 2004-)
      hide Biological Process
      CV term
      Evidence
      References
      antimicrobial humoral response
      non-traceable author statement
      (Lemaitre, 2000.12.20)
      cell wall catabolic process
      inferred from electronic annotation with InterPro:IPR000974
      (FlyBase Curators et al., 2004-)
      hide Cellular Component
      CV term
      Evidence
      References
      extracellular region
      inferred from electronic annotation with InterPro:IPR001916
      (FlyBase Curators et al., 2004-)
      hide Sequence Ontology: Class of Gene
      protein_coding_gene
       
      nuclear_gene
       
      hide Interactions & Pathways
      hide Summary of Genetic Interactions
      Interacts with
      Please look at the allele data for full details of the genetic interactions
      LysE allele
      Gene
      References
      hide External Data
      Linkouts
      BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
      •
      hide Orthologs
      Genome-wide drosophilid orthologs
      Curated drosophilid orthologs
       
      Linkouts
      InParanoid orthologs - Eukaryotic orthologs
      •
      hide Functional Complementation between Species
      hide Inter-Species Misexpression Data
      Produces phenotype in
      Produces NO phenotype in
      hide Stocks & Reagents
      hide Stocks Listed in FlyBase ( 0 )
      hide Genomic Clones ( 1 )
      hide cDNA Clones ( 1 )
      Please Note
      This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
      cDNA Clones, Fully Sequenced
      BDGP DGC clones
      Other clones
      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      hide RNAi & Array Information
      Affy Oligo
      Linkouts
      DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
      •
      GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
      •
      hide Antibody Information
      hide Other Information
      hide Discoverer
      hide Etymology
      hide Identification
      hide Position Effect Variegation Data
      hide Relationship to Other Genes
      Source for database identity of
      Source for database merge of
      Source for merge of: LysE BcDNA:LP07339 Source for merge of LysE BcDNA:LP07339 was a shared cDNA (date:030728).
      (FlyBase, 1996-)
      Additional comments
      hide Comments About Role
      hide Comments About Molecular Function
      hide Other Comments
      FlyBase curator comment: The reference to "LysE" on page 19 is a typographical error - the gene meant is LysC. See Misra, 2004.1.7, personal communication to FlyBase.
      (Misra et al., 2002)
      The strain whose genome sequence is reported in FBrf0155827 is mutant at LysC, not LysE as was reported on page 19 of FBrf0155827.
      (Misra, 2004.1.7)
      hide External Crossreferences & Linkouts
      Sequence Crossreferences
      RefSeq (Transcripts)
      •
      RefSeq (Proteins)
      •
      DDBJ / EMBL / GenBank
      •
      UniProtKB/Swiss-Prot
      •
      UniProtKB/TrEMBL
      •
      Other Crossreferences
      InterPro domains - A database of protein families, domains, and functional sites
      •
      Glycoside hydrolase, family 22, lysozyme (IPR000974)
      Glycoside hydrolase, family 22 (IPR001916)
      Linkouts
      BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
      •
      DEDB - Drosophila exon database: splicing graphs
      •
      DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
      •
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      •
      FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
      •
      GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
      •
      GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
      •
      InParanoid orthologs - Eukaryotic orthologs
      •
      PANTHER - Protein classification by function, families, and pathways
      •
      hide Synonyms & Secondary IDs ( 5 )
      Reported As
      Symbol Synonym
      BcDNA:LP07339
       
      CG1180
       
      LysE
      (Waterhouse et al., 2007, )
      lysE
      (Lemaitre, 2000.12.20)
      Name Synonym
      Lysozyme E
       
      Secondary FlyBase IDs
      • FBgn0002575
      • FBgn0063103
      hide References ( 22 )
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      hide Recent research papers ( 1 )
      Waterhouse et al., 2007, Science 316(5832): 1738--1743
      Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. [FBrf0200242]
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