Gene Dmel\LysC

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General Information

Symbol

Dmel\LysC

Species

D. melanogaster

Name

Lysozyme C

Annotation symbol

CG9111

Feature type

protein_coding_gene

FlyBase ID

FBgn0004426

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

61F3-61F3

Sequence location

3L:1,210,485..1,210,971 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Lysozyme C is referred to in FlyBase by the symbol LysC (CG9111, FBgn0004426). It has the cytological map location 61F3. Its sequence location is 3L:1210485..1210971. Its molecular function is described as lysozyme activity. It is involved in the biological processes: antimicrobial humoral response; cell wall catabolic process. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

61F3-61F3

Limits computationally determined from genome sequence between P{PZ}l(3)05967⁰⁵⁹⁶⁷ and P{PZ}l(3)02640⁰²⁶⁴⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

61F-61F

(determined by in situ hybridisation)

(Kylsten et al., 1988)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Overall orientation not stated: LysB+ LysC+ LysD- LysE+ LysP- LysS+

(Daffre et al., 1994)

Gene Model & Products

Please see the GBrowse view of Dmel\LysC for information on other features

Comments on Gene Model

Replace with wild type seqeunce from GenBank accession NM_080513

Known mutation in sequenced strain: premature stop

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

LysC-RA

FBtr0072629

NM_080130

487

140

Additional Transcript Data & Comments

Reported size (kB)

0.480 (longest cDNA)

(Daffre et al., 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

LysC-PA

FBpp0072525

15.7

140

5.58

NP_524869

AAF47449

Additional Polypeptide Data & Comments

Reported size (kD)

140 (aa)

(Daffre et al., 1994)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Glycoside hydrolase, family 22, lysozyme (IPR000974)

Glycoside hydrolase, family 22 (IPR001916)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P83971

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

adult stage

adult midgut

(Daffre et al., 1994)

larval stage,adult stage

(Daffre et al., 1994)

larval stage

embryonic/larval midgut

(Daffre et al., 1994)

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0004426

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0004426

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of LysC	Class	Mutagen	Stocks	Known lesion
LysC¹			2	--

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of LysC	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Useful deficiency

Df(3L)bab-PG

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Lysozymes are expressed at a high level mainly in the digestive tract, they are not a component of the haemolymph. Lysozyme is not induced by bacteria so is not part of the inducible immune response but instead has been recruited for digestion of symbiotic bacteria in the stomach.

(Daffre et al., 1994)

Gene Ontology: Function, Process & Cellular Component ( 4 )

Molecular Function

CV term

Evidence

References

lysozyme activity

inferred from sequence or structural similarity

(Daffre et al., 1994)

non-traceable author statement

(Lemaitre, 2000.12.20)

inferred from electronic annotation with InterPro:IPR000974

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

antimicrobial humoral response

non-traceable author statement

(Lemaitre, 2000.12.20)

cell wall catabolic process

inferred from electronic annotation with InterPro:IPR000974

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

extracellular region

inferred from electronic annotation with InterPro:IPR001916

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

LysC allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

63672

Orthologs

Genome-wide drosophilid orthologs

Dpse\GA28485

Dsim\GD13593

Curated drosophilid orthologs

Dpse\GA21550

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSXETP00000040356
Xenopus tropicalis (Ensembl)
ENSXETP00000028567
Xenopus tropicalis (Ensembl)
ENSANGP00000017888
Anopheles gambiae (Ensembl)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

Bloomington

2057

y¹ oc^R3.2; Gr22b¹ Gr22d¹ cn¹ CG33964^R4.2 bw¹ sp¹; LysC¹ lab^R4.2 MstProx¹ GstD5¹ Rh6¹ <E>

Tucson

14021-0231.36

y¹ oc^R3.2; Gr22b¹ Gr22d¹ cn¹ CG33964^R4.2 bw¹ sp¹; LysC¹ lab^R4.2 MstProx¹ GstD5¹ Rh6¹ <E>

Genomic Clones ( 1 )

BACR22D12

cDNA Clones ( 1 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

EC34186

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0004426

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0004426

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

FlyBase curator comment: The reference to "LysE" on page 19 is a typographical error - the gene meant is LysC. See Misra, 2004.1.7, personal communication to FlyBase.

(Misra et al., 2002)

The strain whose genome sequence is reported in FBrf0155827 is mutant at LysC, not LysE as was reported on page 19 of FBrf0155827.

(Misra, 2004.1.7)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_080130

RefSeq (Proteins)

•

NP_524869

DDBJ / EMBL / GenBank

•

UniProtKB/Swiss-Prot

•

P83971

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Glycoside hydrolase, family 22, lysozyme (IPR000974)

Glycoside hydrolase, family 22 (IPR001916)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

63672

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0004426

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0004426

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0004426

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0004426

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0004426

InParanoid orthologs - Eukaryotic orthologs

•

ENSXETP00000040356
Xenopus tropicalis (Ensembl)
ENSXETP00000028567
Xenopus tropicalis (Ensembl)
ENSANGP00000017888
Anopheles gambiae (Ensembl)

Synonyms & Secondary IDs ( 4 )

Reported As

Symbol Synonym

CG9111

LysC

(Waterhouse et al., 2007, )

lysC

(Lemaitre, 2000.12.20)

Name Synonym

Lysozyme C

Secondary FlyBase IDs

FBgn0002575

References ( 21 )

Generate a list of

All references relating to this gene ( 21 )

List References by type

Recent research papers ( 1 )

Waterhouse et al., 2007, Science 316(5832): 1738--1743: Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. [FBrf0200242]

Show all research papers ...

Recent reviews (0)

All reviews listed in FlyBase were published before 2006

Show reviews ...