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Gene Dmel\S

General Information
Symbol	Dmel\S	Species	D. melanogaster
Name	Star	Annotation symbol	CG4385
Feature type	protein_coding_gene	FlyBase ID	FBgn0003310
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map	2-1.3
Cytogenetic map	21E4-21E4	Sequence location	2L:1,050,877..1,077,811 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Star is referred to in FlyBase by the symbol S (CG4385, FBgn0003310). It has the cytological map location 21E4. Its sequence location is 2L:1050877..1077811. Its molecular function is unknown. It is involved in the biological processes described with 13 unique terms, many of which group under: anatomical structure development; transmembrane receptor protein tyrosine kinase signaling pathway; organ development; enzyme linked receptor protein signaling pathway; organ morphogenesis; embryonic development; cellular macromolecule metabolic process; gamete generation; regulation of epidermal growth factor receptor signaling pathway; protein targeting to Golgi. 143 alleles are reported. The phenotypes of these alleles are annotated with 60 unique terms, many of which group under: organ system; nervous system; peripheral nervous system; embryonic nervous system; adult segment; adult mesothoracic segment; embryonic neuron; commissure; embryonic/larval tracheal system; embryonic hindgut. It has 2 annotated transcripts and 2 annotated polypeptides.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	S: Star Eyes slightly smaller and narrower than wild type; texture somewhat rough from rounded, irregular facets. Arrangement of hairs on surface of eye irregular. S/ast has small rough eyes; S ast/+ + is like S/+. Enhanced by E(S); partially suppresses px and net (Bedichek, 1936, DIS 5: 24; Lewis, 1945). Homozygote dies in late embryonic stage (Sivertzev-Dobzhansky, 1927, Wilhelm Roux's Arch. Entwicklungsmech. Organ. 109: 535-48; Sonnenblick and Huettner, 1938, Genetics 23: 169). A member of the so-called spitz group of mutants; embryos lack structures derived from ventral-lateral region of blastoderm. Denticle bands narrow and ventral arms of head skeleton fused. Anal pads reduced. Transverse commisures of ventral nervous system reduced; Keilin organs, maxillary and antennal sense organs strongly reduced. Lethal in homozygous clones in female germ line (Nusslein-Volhard, Wieschaus, and Kluding, 1984, Wilhelm Roux's Arch. Dev. Biol. 193: 267-82; Mayer and Nusslein-Volhard). RK1.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 21E4-21E4   Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
Experimentally Determined Cytological Location
Cytogenetic map Notes References 21E2-21E2   (Prokopenko, 1999.8.3) 21D2-21D3 (determined by in situ hybridisation)   (Spradling et al., 1999) 21E1-21E2 (determined by in situ hybridisation)   (Forjanic et al., 1997) 21E-21F (determined by in situ hybridisation)   (Kania et al., 1995) 21E1-21E2 (determined by in situ hybridisation)   (Kotarski et al., 1991) 21C6-21C7 21E1--2 21E1--3 21E2--3 21E3--4   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-1.3 (Reuter and Szidonya, 1983, Tearle and Nusslein-Volhard, 1987, Waletzky, 1939) 2- (Neufeld et al., 1998)
Left of (cM)	ast (Lewis, 1945)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: S- ast+ (Kotarski et al., 1998)
Gene Model & Products
Please see the GBrowse view of Dmel\S for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) S-RA FBtr0077994  NM_164403   3182   597 S-RB FBtr0077993  NM_078726   3999   597
Additional Transcript Data & Comments
Reported size (kB)	4.0 (northern blot) (Kolodkin et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein S-PA   FBpp0077659   65.8   597   7.98     NP_722674   AAF51425 S-PB   FBpp0077658   65.8   597   7.98     NP_523450   AAN10478
Additional Polypeptide Data & Comments
Reported size (kD)	597 (aa); 66 (kD predicted) (Kolodkin et al., 1994)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0003310
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA438599   AA950739   AE003587 AAF51425   AE003587 AAN10478   AF174675   AF174676   AI403375   AQ025780   AQ025896   AY113201 AAM29206   BF485912   BF495387   BF504778   BG638616   BI374709   BI375222   BI633836   BP554495   CL844419   CO262198   CO268587   CO276275   CO278697   CO295216   CO298104   CO323596   CO342244   CZ466184   CZ472344   EC057505   EC068165   EC081862   EC081863   EC082507   EC085356   EC087738   EC195168   EC196369   EC196582   EC198182   EC202511   EC220249   EC220368   EC226082   EC233201   EC235117   EC236118   EC254812   G00465   L31886 AAB04161   LD30846   Z31977   Z32315
UniProtKB/Swiss-Prot	P42519
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with	AT04225 (BDGP Project Members, 2000-) LD12914 (Ruden et al., 1999) Dm0093 (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation S[54] 2L:1,052,808..1,052,808 evidence=experimental na_change=C1052808T pr_change=Q387|S-PA,Q387|S-PB reported_pr_change=Q387@
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 5751
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage  midline glial cell (Kolodkin et al., 1994)  embryonic stage  mesectoderm (Kolodkin et al., 1994)  larval stage | third instar  eye-antennal disc (Kolodkin et al., 1994)  larval stage | third instar  photoreceptor cell R5 | presumptive (Kolodkin et al., 1994)  larval stage | third instar  morphogenetic furrow (Kolodkin et al., 1994)  larval stage | third instar  photoreceptor cell R2 | presumptive (Kolodkin et al., 1994)  larval stage | third instar  photoreceptor cell R8 | presumptive (Kolodkin et al., 1994)  embryonic stage  optic lobe placode (Kolodkin et al., 1994)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AA950739
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0003310 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0003310 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0003310
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable SK lethal | recessive S07056 S104E S1 S2J1 S51 SBA651 SKoj-R1 SKoj-R2 SKoj-R3 SKoj-R4 SKoj-R5 SKoj-R6 SSC10 SSC11 SSC12 SSC1 SSC2 SSC3 SSC4 SSC5 SSC6 SSC7 SSC8 SSC9 SSCG10 SSCG11 SSCG12 SSCG1 SSCG2 SSCG3 SSCG4 SSCG5 SSCG6 SSCG7 SSCG8 SSCG9 SSCP1 SSCP2 SSCP3 SU132 Sc00080 Sdb123 SeAA2 SeAD7 SeAG4 SeAG5 SeAL11 SeAN5 SeAO3 SeAQ3 SeAS5 SeCJ9 SeDO3 SeE6 SeO7 SeQ10 SeT6 SeW4 Sk06101 Sk06920 Sk09312 Sk09530 Sk09534 Sk09538a Sk09541 Sk10232 Sk14005 Sk14020 Sk15907 Sk17024 Sunspecified lethal | embryonic stage S1 lethal | embryonic stage | maternal effect | recessive SKoj-R1 SKoj-R3 SKoj-R5 lethal | embryonic stage | recessive S05671 S126 S218 S528 S606 S7051 SF126 SX155 Sk06921 Sk09530 Sk09531 SrK134 Sunspecified lethal | embryonic stage | germ-line clone SKoj-R1 SKoj-R3 SKoj-R5 Other Phenotypes Allele wild-type, with Scer\GAL4CY2 SScer\UAS.cBa visible S07056 S1 SL SM SW SX155 SX Sdb123 visible | dominant S05671 S104E S1 S51 S54 SKoj-R4 SKojak SeAA2 SeAD7 SeAG4 SeAG5 SeAL11 SeAN5 SeAO3 SeAQ3 SeAS5 SeCJ9 SeDO3 SeE6 SeO7 SeQ10 SeT6 SeW4 Sk09530 Sunspecified visible, with Scer\GAL4Bx-MS1096 SScer\UAS.cGb visible, with Scer\GAL4GMR.PF SScer\UAS.cGa cell polarity S05671 S48-5 neuroanatomy defective SIIN Sterility Allele female sterile | recessive SKoj-R2 SKoj-R4 SKoj-R6 female sterile | dominant SKojak female sterile soma-dependent | dominant SKojak female fertile SKoj-R1 SKoj-R3 SKoj-R5 Phenotype manifest in Allele eye S05671 S07056 S1 S104E S51 S54 S606 SL SM SW SX Sdb123 Shs.sev Sunspecified embryonic central nervous system S05671 S126 S218 S7051 SF126 SX155 Sk06921 SrK134 Sunspecified photoreceptor cell R2 S05671 photoreceptor cell R5 S05671 photoreceptor cell R8 S05671 wing vein L2 S05671 wing vein L3 S05671 wing vein L4 S05671 wing vein L5 S05671 ommatidium S05671 S1 S48-5 S51 S54 S606 SL SM SW Sdb123 SeAA2 SeAD7 SeAG4 SeAG5 SeAL11 SeAN5 SeAO3 SeAQ3 SeAS5 SeCJ9 SeDO3 SeE6 SeO7 SeQ10 SeT6 SeW4 Shs.7 Shs.8 photoreceptor S05671 mesothoracic tibial bract S05671 mesothoracic tarsal segment 1 & bract S05671 longitudinal connective S1 Sunspecified midline glial cell S1 S126 Sunspecified VUM1 neuron S1 VUM2 neuron S1 VUM3 neuron S1 VUM4 neuron S1 VUM5 neuron S1 VUM6 neuron S1 MP1 neuron S1 anterior commissure S1 posterior commissure S1 eye photoreceptor cell S1 S104E S218 Shs.7 Shs.8 denticle belt | ventral S1 SIIN Keilin's organ S1 SIIN Sunspecified ovariole | germ-line clone S1 SIIN SKoj-R2 SKoj-R4 SKoj-R6 interommatidial bristle S1 SKoj-R4 SKojak eye | somatic clone S126 S218 S606 SX155 dorsal neurohemal organ S126 denticle belt S218 SF126 Sunspecified embryonic/first instar larval cuticle S218 SKoj-R2 dorsal appendage | maternal effect | somatic clone S218 photoreceptor cell S48-5 ommatidium | somatic clone S606 wing vein, with Scer\GAL4Bx-MS1096 SDN.Scer\UAS SNeo1.Scer\UAS wing vein L2, with Scer\GAL4Bx-MS1096 SDN.Scer\UAS embryonic ventral epidermis SIIN abdominal lch5 neuron SIIN genital disc primordium SIIN embryonic/larval somatic muscle SIIN ventral nerve cord SIIN commissure SIIN Sunspecified embryonic posterior Malpighian tubule SIIN embryonic anterior Malpighian tubule SIIN ventral midline glial cell SIIN embryonic/larval dorsal trunk SIIN embryonic/larval trachea SIIN macrochaeta SKoj-R1 SKoj-R2 SKoj-R3 SKoj-R4 SKoj-R5 SKoj-R6 SKojak embryonic/first instar larval cuticle | germ-line clone | maternal effect SKoj-R1 SKoj-R3 SKoj-R5 embryonic/first instar larval cuticle | maternal effect SKoj-R1 SKoj-R3 egg chamber SKojak dorsocentral bristle SKojak scutellar bristle SKojak nurse cell SKojak oocyte SKojak wing, with Scer\GAL4Bx-MS1096 SNeo1.Scer\UAS SScer\UAS.cGb wing margin, with Scer\GAL4Bx-MS1096 SNeo1.Scer\UAS eye, with Scer\GAL4GMR.PF SScer\UAS.cGa midline glial cell, with Scer\GAL4elav.PLu SScer\UAS.cGa wing vein | ectopic, with Scer\GAL4Bx-MS1096 SScer\UAS.cGb wing vein | germ-line clone SX155 wing vein L2 | germ-line clone SX155 wing vein L3 | germ-line clone SX155 wing vein L4 | germ-line clone SX155 dorsal appendage, with Scer\GAL4unspecified Sa.Scer\UAS.P\T embryonic peripheral nervous system Sk06921 Sk09530 Sk09531 Sunspecified chordotonal organ | lateral Sk06921 Sk09530 Sk09531 fascicle Sk09530 Sk09531 wing Sk09530 embryonic ventral nervous system Sunspecified anal pad Sunspecified cephalopharyngeal skeleton Sunspecified larval sense organ & antennal segment Sunspecified larval sense organ & maxillary segment Sunspecified sensory neuron Sunspecified motor neuron Sunspecified
Classical Alleles ( 123 )
For All Classical Alleles Show
Allele of S Class Mutagen Stocks Known lesion S05671 P-element activity 0 -- S07056 P-element activity 0 -- S104E X ray 0 -- S11 γ ray 0 -- S126 P-element activity 0 -- S1 spontaneous 63 Yes S218 ethyl methanesulfonate 0 -- S2 spontaneous 15 -- S2J1 ethyl methanesulfonate 0 -- S30 heat-treatment 0 -- S32c heat-treatment 0 -- S39b spontaneous 0 -- S48-5 0 -- S51 U.V. 0 -- S528 0 -- S54 ethyl methanesulfonate 0 Yes S55 ethyl methanesulfonate 0 -- S56 ethyl methanesulfonate 0 -- S57 ethyl methanesulfonate 0 -- S58</