A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Rsp

General Information
SymbolDmel\RspSpeciesD. melanogaster
NameResponder to SdAnnotation symbol
Feature typerepeat_regionFlyBase IDFBgn0003284
Created / Updated2006-08-22/2006-08-22
Genomic Location
Chromosome (arm)Recombination map2-56.61
Cytogenetic maph38-h38Sequence location
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Responder to Sd is referred to in FlyBase by the symbol Rsp (FBgn0003284). It has the cytological map location h38. It has not been localized to the genome sequence. Its molecular function is unknown. The biological processes in which it is involved are not known. 16 alleles are reported. No phenotypic data is available. It has no annotated transcripts.

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
Rsp: Responder
The region of the chromosome upon which Sd acts to cause dysfunction of sperm that receive it; the sensitivity of Rsp is unaffected by its position in the genome, being equally responsive to Sd either in repulsion or coupling with Sd, or when located ectopically as in Dp(2;f)Rsp (Brittnacher and Ganetzky, 1989, Genetics 121: 739-50) or in Dp(2;Y)Rsp (Lyttle and Ault, 1985, Genetics 110: s23; Lyttle, 1989, Genetics 121: 751-63).
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
h38-h38  
Left limit from inclusion within Tp(2;Y)cb25-24 (FBrf0049925) Right limit from inclusion within Tp(2;Y)cb25-24 (FBrf0049925)  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
h39-h39
 
(Marsano, 2002.9.16)
Experimentally Determined Recombination Data
Location
2-56.61
 
Left of (cM)
(Ganetzky, 1977)
(Sharp et al., 1985)
Right of (cM)
(Sharp et al., 1985)
Notes
Mapping based on 122 pr-cn recombinants.
 
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AJ508242
 
M21213
 
M21214
 
U53805
 
U53806
 
U53807
 
U53808
 
U53809
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Maps to
      Does NOT map to
      Identified with
      (BDGP Project Members, 1994-1999)
      hide Mapped Features & Mutations
      Type
      Symbol & Location
      Additional Notes
      References
      hide External Data
      Linkouts
      Crossreferences
      hide Expression Data
      FlyBase-Curated Data
      Transcript and
      Protein data       		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
      hide Summary of Transcript Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Summary of Polypeptide Expression
        Stage
        Tissue/Position
        Reference
        Marker for
          Subcellular Localization
          CV Term
          hide External Data & Images
          Linkouts
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          •
          hide Alleles & Phenotypes
          hide Summary of Allele Phenotypes
          Lethality
          Allele
          viable
          Sterility
          Allele
          fertile
          Phenotype manifest in
          Allele
          hide Classical Alleles ( 16 )
          For All Classical Alleles Show

          Allele of RspClassMutagenStocksKnown lesion
          Rspi-C1110 --
          Rspi-C1820 --
          Rspi-C25-30 --
          Rspi-MM1130 --
          Rspi160 --
          Rspi320 --
          Rspi
            		0 --
            Rsps-C1150 --
            Rsps-C1710 --
            Rsps-C550 --
            Rsps
              		0 --
              Rspsi
                		0 --
                Rspss-MM1530 --
                Rspss-MM2040 --
                Rspss-MM330 --
                Rspss0 --
                hide Alleles Carried on Transgenic Constructs ( 0 )
                For All Alleles Carried on Transgenic Constructs Show

                Allele of RspClassMutagenStocksKnown lesion
                hide Aneuploid Aberrations
                Disrupted in
                (Ganetzky, 1977, Dimitri, 1991, Berghella and Dimitri, 1996)
                (Pimpinelli and Dimitri, 1989, Moschetti et al., 1996)
                Duplicated in
                (Lyttle, 1989)
                (Lyttle, 1989)
                (Lyttle, 1989)
                (Pimpinelli and Dimitri, 1989)
                Partially disrupted in
                (Lyttle, 1989)
                (Lyttle, 1989)
                (Lyttle, 1989)
                (Lyttle, 1989)
                (Lyttle, 1989)
                Partially duplicated in
                (Lyttle, 1989)
                (Lyttle, 1989)
                (Lyttle, 1989)
                (Lyttle, 1989)
                (Lyttle, 1989)
                (Lyttle, 1989)
                Not disrupted in
                (Eberl et al., 1993)
                (Eberl et al., 1993)
                (Eberl et al., 1993)
                (Eberl et al., 1993)
                (Eberl et al., 1993)
                hide Transgenic Constructs & Insertions
                Transgenic Constructs
                Type of construct
                Name
                Expression data
                Insertions
                Type of insertions
                Name
                Expression data
                hide Related Comments
                Please look at the allele reports for the complete phenotype data
                In flies without SD, deletion of the Rsp region results in flies (both male and female) that are less fit than Rsp+ flies.
                (Wu et al., 1989)
                To investigate how SD behaves and is maintained in nature the major components of the SD system have been examined in two natural populations.
                (Temin and Marthas, 1984)
                Dp(2;Y)Sd causes dysfunction of Rsps bearing sperm indicating that Rsp activity does not depend on pairing with a normal autosomal homologue.
                (Lyttle, 1986)
                A possible relationship between the SD system of segregation distortion and the P, I and hobo transposable element systems has been suggested.
                (Golic, 1990)
                Rsp is the target for the action of RanGapSD and can exist in a sensitive or insensitive state. E(SD)unspecified distortion is mediated via Rsp, whether Rsp is on the Y or second chromosome. E(SD)unspecified is independently capable of acting on Rsp and is not a simple modifier of RanGapSD.
                (Temin, 1991)
                The recessive semi-lethality caused by Df(2R)Rsp16, and previously suggested to be due to the deletion of Rsp, may actually be at least partly due to the deletion of closely linked Bari1.
                (Caizzi et al., 1993)
                Analysis of the large scale molecular structure of Rsp reveals that Rsp repeats isolated from one chromosome are not more similar than those from a different chromosome, the repeats usually have a dimeric structure and frequent unequal crossover events can obscure the phylogenetic relationships between repeats.
                (Cabot et al., 1993)
                hide Gene Ontology: Function, Process & Cellular Component ( 0 )
                hide Molecular Function
                CV term
                Evidence
                References
                hide Biological Process
                CV term
                Evidence
                References
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                CV term
                Evidence
                References
                hide Sequence Ontology: Class of Gene
                repeat_region
                 
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                Interacts with
                Please look at the allele data for full details of the genetic interactions
                Rsp allele
                Gene
                References
                unspecified
                E(SD)
                 
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                Linkouts
                hide Orthologs
                Genome-wide drosophilid orthologs
                Curated drosophilid orthologs
                Linkouts
                hide Functional Complementation between Species
                hide Inter-Species Misexpression Data
                Produces phenotype in
                Produces NO phenotype in
                hide Stocks & Reagents
                hide Stocks Listed in FlyBase ( 0 )
                hide Genomic Clones ( 0 )
                hide cDNA Clones ( 0 )
                cDNA Clones, Fully Sequenced
                BDGP DGC clones
                Other clones
                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
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                Affy Oligo
                Linkouts
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                hide Identification
                hide Position Effect Variegation Data
                hide Relationship to Other Genes
                Source for database identity of
                Source for database merge of
                Additional comments
                hide Comments About Role
                hide Comments About Molecular Function
                The sensitivity of Rsp to RanGapSD depends on the size of the h39 band: this demonstrates that the Rsp locus is composed of repeated DNA.
                (Pimpinelli and Dimitri, 1989)
                hide Other Comments
                All naturally occurring SD chromosomes carry RanGapSD and Rspi. Typical SD+ chromosomes carry Rsps and its presence is sufficient to render a chromosome sensitive to the action of RanGapSD. Some SD+ chromosomes carry Rspi. To cause high levels of distortion, RanGapSD requires the presence of a series of upward modifiers known as E(SD)unspecified, St-SDunspecified and M(Sd)unspecified.
                (Kusano et al., 2003)
                Spontaneous and radiation-induced recombination analyses and deficiency studies of the SD-5 chromosome provide evidence that the Rsp locus lies within the proximal heterochromatin of the right arm of chromosome 2.
                (Sharp et al., 1985)
                Rsp is the most proximal known locus within the 2R heterochromatin: determined by free duplications for the centromeric region of the second chromosome and their sensitivity to distortion.
                (Brittnacher and Ganetzky, 1989)
                Rsp has been mapped as the most proximal locus in 2R heterochromatin by cytology and lethal complementation tests of autosomal insertions into the long arm of the Y chromosome. This suggests that Rsp is separable from the second chromosome centromere and its behaviour does not depend on gross chromosomal position.
                (Lyttle, 1989)
                Structural role of Rsp is determined by preferentially perturbing the locus using Hoechest 33258.
                (Doshi et al., 1991)
                hide External Crossreferences & Linkouts
                Sequence Crossreferences
                DDBJ / EMBL / GenBank
                •
                Other Crossreferences
                Linkouts
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                •
                hide Synonyms & Secondary IDs ( 11 )
                Reported As
                Symbol Synonym
                Ac-SD
                (Hiraizumi and Nakazima, 1965)
                Dr
                 
                Rsp
                (Sinkins and Gould, 2006, )
                rsp
                (Coelho et al., 1996)
                Rsp-Sd
                 
                Name Synonym
                Activator of SD
                (Hiraizumi and Nakazima, 1965)
                Director
                 
                Receptor
                 
                Receptor-of-SD
                 
                Responder
                (Lyttle, 2002, Saito et al., 2006)
                Responder to Sd
                 
                Secondary FlyBase IDs
                  hide References ( 84 )
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                  hide Recent research papers ( 1 )
                  Saito et al., 2006, Genes Dev. 20(16): 2214--2222
                  Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. [FBrf0191820]
                  Show all research papers ...
                  hide Recent reviews ( 1 )
                  Sinkins and Gould, 2006, Nature Rev. Genet. 7(6): 427--435
                  Gene drive systems for insect disease vectors. [FBrf0193510]
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