Gene Dmel\esg

General Information
Symbol	Dmel\esg	Species	D. melanogaster
Name	escargot	Annotation symbol	CG3758
Feature type	protein_coding_gene	FlyBase ID	FBgn0001981
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35D2-35D2	Sequence location	2L:15,333,864..15,336,150 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene escargot is referred to in FlyBase by the symbol esg (CG3758, FBgn0001981). It has the cytological map location 35D2. Its sequence location is 2L:15333864..15336150. Its molecular function is described as: specific RNA polymerase II transcription factor activity; RNA polymerase II transcription factor activity; DNA binding; electron carrier activity; zinc ion binding; nucleic acid binding. It is involved in the biological processes: maintenance of imaginal histoblast diploidy; regulation of transcription from RNA polymerase II promoter; fusion cell fate specification; open tracheal system development; peripheral nervous system development; branch fusion, open tracheal system; regulation of compound eye pigmentation; olfactory behavior; asymmetric neuroblast division. 107 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: peripheral nervous system; embryonic/larval dorsal branch; organ system; embryonic/larval tracheal system; nervous system; adult segment; adult; imaginal precursor; tracheal system; thoracic segment. It has one annotated transcript and one annotated polypeptide.
External Summaries

Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35D2-35D2 Limits computationally determined from genome sequence between P{EP}esg^EP633&P{PZ}esg⁰⁷⁰⁸² and P{lacW}CycE^k05007&P{lacW}CycE^k02602
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35D1-35D2 (determined by in situ hybridisation) (Abdelilah-Seyfried et al., 2000) 35C3-35C3 (Prokopenko, 1999.8.3) 35D1-35D2 (determined by in situ hybridisation) 35D1--4 (determined by in situ hybridisation) 35D3--4 (determined by in situ hybridisation) 35C1--3 (determined by in situ hybridisation) (Ashburner et al., 1999) 35D1-35D2 (determined by in situ hybridisation) (Spradling et al., 1999) 35E-35E (determined by in situ hybridisation) (Rodriguez et al., 1996) 35D-35D (determined by in situ hybridisation) (Kania et al., 1995) 35D1-35D2 (determined by in situ hybridisation) 35D1--35D4 (determined by in situ hybridisation) (BDGP Project Members, 1994-1999) 35C-35C (determined by in situ hybridisation) (Whiteley et al., 1992) 35C-35C (determined by in situ hybridisation) (Hayashi et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: nht- esg+ CG18482- (Ashburner et al., 1999) Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\esg for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) esg-RA FBtr0080734 NM_057252 2287 470
Additional Transcript Data & Comments
Reported size (kB)	2.3 (northern blot) (Whiteley et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein esg-PA FBpp0080293 52.0 470 6.87 NP_476600 AAF53458
Additional Polypeptide Data & Comments
Reported size (kD)	470 (aa) (Whiteley et al., 1992)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0001981
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Rubredoxin-type Fe(Cys)4 protein (IPR004039) Zinc finger, C2H2-subtype (IPR007086) Zinc finger, C2H2-type (IPR007087) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880) TRANSFAC - Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles • T02329
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AC092247 AE003412 AAF44940 AE003647 AAF53458 AF174681 AQ025707 AQ025724 AQ025731 AQ025738 AQ025743 AQ025766 AQ025807 AQ025814 AQ025861 AQ025887 AQ026087 AQ026091 AQ026128 AQ026460 AQ026472 AQ026473 AQ073562 AQ074113 AQ254835 AY071590 AAL49212 BI481675 BP550365 BP550366 BP551237 BP551238 BP555841 BP555842 CO191034 CO192553 CO298103 CO304090 CO316360 CO325197 CO344392 CZ474794 DQ017420 AAY82202 DQ017421 AAY82203 EC073874 EC080953 EC215310 EC227826 EC246852 EC248150 G00416 G00610 L80117 M83207 AAA28513

UniProtKB/Swiss-Prot	P25932
UniProtKB/TrEMBL	Q3YND2

Maps to	DS07851 (Ashburner et al., 1999.10.12) FBcl0297554 (FlyBase, 1992-)
Does NOT map to
Identified with	RE64266 (BDGP Project Members, 2000-) Dm0011 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Ashburner et al., 1999) Dm0348 (BDGP Project Members, 1994-1999, Ashburner et al., 1999) D1300 (BDGP Project Members, 1994-1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation esg[35Ce-3] 2L:15,335,253..15,335,253 comment=Amino acid change within the zinc finger: two other amino acid substitutions, P149Q and M196I, observed in mutant. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental pr_change=G387E\|esg-PA reported_pr_change=G387E (Fuse et al., 1994)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 7741
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference larval stage \| third instar central nervous system (Hayashi et al., 1993) embryonic stage \| stage 14 central nervous system (Hayashi et al., 1993) embryonic stage \| stage 14-16 histoblast nest (Hayashi et al., 1993) embryonic stage \| stage 11 ventral midline (Whiteley et al., 1992) embryonic stage \| stage 14-16 dorsal mesothoracic disc \| presumptive (Hayashi et al., 1993) embryonic stage \| stage 14-16 head (Hayashi et al., 1993) embryonic stage \| stage 14-16 ventral thoracic disc \| presumptive (Hayashi et al., 1993) embryonic stage \| stage 14-16 dorsal metathoracic disc anlagen (Hayashi et al., 1993) embryonic stage \| stage 14 embryonic/larval trachea (Hayashi et al., 1993) embryonic stage \| stage 16 ventral mesothoracic disc (Whiteley et al., 1992) embryonic stage \| stage 16 dorsal metathoracic disc (Whiteley et al., 1992) embryonic stage \| stage 16 histoblast (Whiteley et al., 1992) embryonic stage \| stage 16 dorsal ridge (Whiteley et al., 1992) larval stage \| third instar imaginal disc (Hayashi et al., 1993) embryonic stage \| stage 12 peripheral nervous system (Whiteley et al., 1992) embryonic stage,pupal stage (Whiteley et al., 1992) embryonic stage \| stage 16 dorsal mesothoracic disc (Whiteley et al., 1992) embryonic stage \| stage 8-9 neurectoderm (Whiteley et al., 1992) embryonic stage \| stage 16 ventral metathoracic disc (Whiteley et al., 1992) embryonic stage \| stage 16 genital disc (Whiteley et al., 1992) embryonic stage \| stage 16 ventral prothoracic disc (Whiteley et al., 1992) embryonic stage ectoderm (Whiteley et al., 1992)
Marker for

Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference embryonic stage \| stage 13 nucleus <of> homotip tracheal tip cell (Uemura et al., 1996) embryonic stage \| stage 13 dorsal mesothoracic disc \| presumptive (Fuse et al., 1996) embryonic stage \| stage 15 ventral thoracic disc specific anlage \| restricted & proximal & NOT center (Kubota et al., 2003) embryonic stage \| stage 15 dorsal mesothoracic disc (Fuse et al., 1996) embryonic stage \| stage 13 dorsal metathoracic disc \| presumptive (Fuse et al., 1996) embryonic stage \| stage 15 embryonic/larval anterior spiracle (Fuse et al., 1996) embryonic stage \| stage 15 genital disc \| presumptive (Fuse et al., 1996) embryonic stage \| stage 5 (Fuse et al., 1996) embryonic stage \| stage 15 dorsal metathoracic disc (Fuse et al., 1996) embryonic stage \| stage 15 ventral thoracic disc \| presumptive (Fuse et al., 1996)
Marker for

Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001981 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0001981 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0001981 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for esg Stage(s) 4-6 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable esg^B7-2-22 esg^BG02354 esg^G66-R esg^k03503 esg^k08225 esg^k09122 esg^k15310 lethal esg^CB02017 lethal \| recessive esg⁰⁵⁷²⁹ esg⁰⁵⁷³⁰ esg⁰⁷⁰⁸² esg^35Ce-1 esg^35Ce-3 esg^B7-2-22 esg^G66 esg^L2 esg^L6 esg^M5-4 esg^P1 esg^k00109 esg^k00418 esg^k00606 esg^k01107 esg^k01502 esg^k02706 esg^k02811 esg^k04408 esg^k04802 esg^k05210 esg^k05517 esg^k05818 esg^k05907a esg^k06211 esg^k07018 esg^k07808 esg^k07902 esg^k08104 esg^k08418 esg^k08505 esg^k08610 esg^k08910 esg^k10811 esg^k10817 esg^k14104 esg^k14811 esg^k15418 esg^k15818 esg^k16117 lethal \| recessive, with Scer\GAL4[-]: esg^EP2159 lethal \| embryonic stage \| recessive esg⁰⁵⁷²⁹ esg^35Ce-3 esg^unspecified lethal \| larval stage \| recessive esg^GW21 esg^k08104 lethal \| larval stage \| conditional ts, with Scer\GAL4^l(1)BP-1 esg^Scer\UAS.cFa lethal \| pupal stage \| recessive esg^P1 lethal, with Scer\GAL4^hs.2sev esg^EP2009 esg^EP2408 esg^EP633 esg^EP684 lethal, with Scer\GAL4^en-e16E esg^EP633 semi-lethal \| recessive, with Scer\GAL4[-]: esg^EP2408 Other Phenotypes Allele wild-type esg^hs.PF visible esg^GMR.PL visible \| recessive esg^GW13 esg^GW2 esg^L7 esg^P2 esg^k15711 visible \| dominant, with Scer\GAL4^dpp.blk1 esg^EP633 visible \| dominant, with Scer\GAL4^hs.2sev esg^EP684 visible \| dominant, with Scer\GAL4^bi-omb-Gal4 esg^EP2009 visible \| somatic clone, with Scer\GAL4^Act5C.PI esg^Scer\UAS.cFa visible, with Scer\GAL4^455.2 esg^Scer\UAS.cFa esg^VS8.Scer\UAS visible, with Scer\GAL4^sca-537.4 esg^EP2009 esg^EP684 visible, with Scer\GAL4^elav-C155 esg^Scer\UAS.cFa visible, with Scer\GAL4^en-e16E esg^EP2009 esg^EP2408 esg^EP684 visible, with Scer\GAL4^ap-md544 esg^EP683 visible, with Scer\GAL4^ey.PH esg^EP2009 esg^EP2408 esg^EP633 esg^EP684 olfaction defective esg^BG02354 neurophysiology defective, with Scer\GAL4^elav.PLu esg^EP2009 Sterility Allele female sterile \| recessive esg^k03012a esg^k05332b esg^k15711 female sterile \| recessive, with Scer\GAL4[-]: esg^EP2009 fertile esg^B7-2-22 esg^k03503 esg^k08225 esg^k09122 esg^k15310 Phenotype manifest in Allele histoblast esg⁰⁵⁷²⁹ esg^35Ce-3 dorsal branch 1 esg^35Ce-1 esg^35Ce-3 esg^G66 dorsal branch 2 esg^35Ce-1 esg^35Ce-3 esg^G66 dorsal branch 3 esg^35Ce-1 esg^35Ce-3 esg^G66 dorsal branch 4 esg^35Ce-1 esg^35Ce-3 esg^G66 dorsal branch 5 esg^35Ce-1 esg^35Ce-3 esg^G66 dorsal branch 6 esg^35Ce-1 esg^35Ce-3 esg^G66 dorsal branch 7 esg^35Ce-1 esg^35Ce-3 esg^G66 dorsal branch 8 esg^35Ce-1 esg^35Ce-3 esg^G66 dorsal branch 9 esg^35Ce-1 esg^35Ce-3 esg^G66 dorsal branch 10 esg^35Ce-1 esg^35Ce-3 esg^G66 macrochaeta esg^BG00644 esg^BG00966 esg^BG01289 esg^BG01688 esg^BG01932 esg^BG02183 esg^BG02297 esg^BG02354 esg^BG02638 esg^BG02727 esg^L35D eye, with Scer\GAL4^ey.PH esg^EP2009 esg^EP2408 esg^EP633 esg^EP684 macrochaeta & scutum, with Scer\GAL4^sca-537.4 esg^EP2009 esg^EP684 microchaeta & scutum, with Scer\GAL4^sca-537.4 esg^EP2009 esg^EP684 wing, with Scer\GAL4^en-e16E esg^EP2009 esg^EP2408 esg^EP684 wing, with Scer\GAL4^bi-omb-Gal4 esg^EP2009 wing, with Scer\GAL4^dpp.blk1 esg^EP633 chaeta, with Scer\GAL4^ap-md544 esg^EP683 adult thorax, with Scer\GAL4^ap-md544 esg^EP683 eye, with Scer\GAL4^hs.2sev esg^EP684 thecogen cell, with Scer\GAL4^sca-537.4 esg^EP684 embryonic/larval tracheal system esg^G66 ventral thoracic disc \| somatic clone esg^G66 embryonic/larval dorsal trunk esg^G66 secondary pigment cell \| somatic clone esg^G66 tertiary pigment cell \| somatic clone