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Gene Dmel\bw

General Information
Symbol	Dmel\bw	Species	D. melanogaster
Name	brown	Annotation symbol	CG17632
Feature type	protein_coding_gene	FlyBase ID	FBgn0000241
Created / Updated	2005-01-10/2005-01-10
Genomic Location
Chromosome (arm)	2R	Recombination map	2-104.5
Cytogenetic map	59E2-59E3	Sequence location	2R:19,415,328..19,426,016 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene brown is referred to in FlyBase by the symbol bw (CG17632, FBgn0000241). It has the cytological map location 59E2-59E3. Its sequence location is 2R:19415328..19426016. Its molecular function is described as: ATPase activity, coupled to transmembrane movement of substances; eye pigment precursor transporter activity; ATP binding. It is involved in the biological processes: ommochrome biosynthetic process; eye pigment precursor transport; eye pigment biosynthetic process; pteridine biosynthetic process. 153 alleles are reported. The phenotypes of these alleles are annotated with: pigment cell; pigment granule; eye; wing; hemolymph; ocellus. It has 2 annotated transcripts and 2 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59E2-59E3   Limits computationally determined from genome sequence between P{lacW}l(2)s4830s4830&P{lacW}chrwk06908 and P{PZ}Dcp-102132
Experimentally Determined Cytological Location
Cytogenetic map Notes References 59E1-59E2   (Dreesen et al., 1988)
Experimentally Determined Recombination Data
Location	2-104.5 (Nitasaka et al., 1995, Fernandez Gianotti, 1950) 2-105 (Farmer, 1974)
Left of (cM)	or Kr sp (Ives, 1967)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\bw for information on other features
Comments on Gene Model
	Transposon inserted in intron Known mutation in sequenced strain: premature stop
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) bw-RA FBtr0072117  NM_079100   2732   675 bw-RB FBtr0114457     1256   328
Additional Transcript Data & Comments
Reported size (kB)	3.0, 2.8 (northern blot) (Dreesen et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein bw-PA   FBpp0072026   75.9   675   7.41     NP_523824   AAF47020 bw-PB   FBpp0112949   36.4   328   8.77
Additional Polypeptide Data & Comments
Reported size (kD)	675 (aa) (Dreesen et al., 1988)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0000241
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ABC transporter related (IPR003439) AAA+ ATPase, core (IPR003593) ABC-2 type transporter (IPR013525)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003461 AAF47020   AE003461 AAS64760   AE003461 AAS64761   AF047460   AI109818   AI134596   AI296359   AI514958   AW940450   AY095181   AY119503 AAM50157   CO274492   CO278062   CO290053   CO318495   CO328391   EC084370   EC198618   EC220947   EC226015   EC242196   EC247149   EC250127   EC254209   EL875428   EL875429   L05635 AAA28398   L23543 AAC37214   M20630 AAA28397   Z50313
UniProtKB/Swiss-Prot	P12428
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with	GH12107 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation bw[16] 2R:19,425,440..19,425,441 evidence=experimental na_change=C19425441T pr_change=A78V|bw-PA reported_na_change=C?T reported_pr_change=A78V (Kondrashov et al., 2006.2.14) point mutation bw[19] 2R:19,425,370..19,425,370 evidence=experimental na_change=C19425370T pr_change=Q102@|bw-PA reported_na_change=C?T reported_pr_change=Q102@ (Kondrashov et al., 2006.2.14) rescue fragment bw[+t8.4] 2R:19,414,452..19,430,343 comment=Position of restriction fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=EcoRI-EcoRI_rfrag (Henikoff and Dreesen, 1989, Dreesen et al., 1991) rescue fragment bw[+t3.8] 2R:19,415,462..19,426,849 comment=Position of restriction fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=BglII-BglII_rfrag (Martin-Morris et al., 1993)
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AI134596
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000241 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0000241 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0000241 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for bw Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable bw85f4 bwD bwM58 lethal | recessive bw5 Other Phenotypes Allele wild-type bw+21 bw24 bw4 bw59 bwptm visible bw1153 bw99 bwPrat.PC bwV1 visible | recessive bw609 bw69 bw72 bw75 bw81 bwAD bwCB bwa bwau visible | dominant bwD bwD bwD114 bwunspecified eye color defective bw1 bw2 bw24 bw24 bw2b bw2c bw30 bw33f bw33g bw37g bw38j bw4 bw45a bw47j bw5 bw53l bw609 bw69 bw72 bw75 bw81 bwA1 bwA2 bwAD bwB1 bwB2 bwC1 bwC4 bwC5 bwC65 bwCB bwD bwD bwD bwD1 bwD114 bwDSu169 bwDa bwDe bwDe2 bwE1 bwE2 bwE3 bwIG281 bwM58 bwM590 bwMi59 bwPrat.PC bwR12 bwR14 bwR15 bwR18 bwR20 bwR27 bwR3 bwR32 bwR33 bwR35 bwR4 bwR40 bwR45 bwR47 bwR55 bwR56 bwR57 bwR58 bwR67 bwR68 bwR73 bwR79 bwRa bwV21Δ116 bwV30a bwV34k bwa bwau bwle bwunspecified eye color defective | recessive bwDa bwDe bwDe2 bwG bwIG281 bwKN1 bwKN2 bwKN3 bwKN4 bwKN5 bwKN6 bwKN7 bwN bwR25 bwS eye color defective | dominant bwV1 bwV2 bwV29l bwV3 bwV30k1 bwV30k10 bwV30k12 bwV30k18 bwV32g bwV34k bwV4 bwV40b bwV5 bwV54a bwV54b bwV54c bwV57e bwV6 bwV7 bwV8 bwVD bwVDe1 bwVDe2 bwVDe3 bwVDe4 bwVI enhancer of variegation, with lawcp1 bwD chemical resistant | dominant | male bw1 chemical resistant | male bw1 Sterility Allele fertile bwD bwM58 Phenotype manifest in Allele pigment cell bw1 bw2 bw24 bw2b bw2c bw30 bw33f bw33g bw37g bw38j bw4 bw45a bw47j bw5 bw53l bw609 bw69 bw72 bw75 bw81 bwA1 bwA2 bwAD bwB1 bwB2 bwC1 bwC4 bwC5 bwC65 bwCB bwD bwD1 bwD114 bwDSu169 bwDa bwDe bwDe2 bwE1 bwE2 bwE3 bwG bwIG281 bwKN1 bwKN2 bwKN3 bwKN4 bwKN5 bwKN6 bwKN7 bwM58 bwM590 bwMi59 bwN bwPrat.PC bwR12 bwR14 bwR15 bwR18 bwR20 bwR25 bwR27 bwR3 bwR32 bwR33 bwR35 bwR4 bwR40 bwR45 bwR47 bwR55 bwR56 bwR57 bwR58 bwR67 bwR68 bwR73 bwR79 bwRa bwS bwV1 bwV2 bwV21Δ116 bwV29l bwV3 bwV30a bwV30k1 bwV30k10 bwV30k12 bwV30k18 bwV32g bwV34k bwV4 bwV40b bwV5 bwV54a bwV54b bwV54c bwV57e bwV6 bwV7 bwV8 bwVD bwVDe1 bwVDe2 bwVDe3 bwVDe4 bwVI bwa bwau bwle bwunspecified pigment granule bw1 ocellus bw99 wing bwD eye bwM58 hemolymph bwR47 bwR56
Classical Alleles ( 136 )
For All Classical Alleles Show
Allele of bw Class Mutagen Stocks Known lesion bw+21 isoallele X ray 0 -- bw+ 0 -- bw108 natural population 0 -- bw111 natural population 0 -- bw1153 X ray 0 -- bw16 ethyl methanesulfonate 1 Yes bw19 ethyl methanesulfonate 1 Yes bw1 spontaneous 1054 Yes bw24 X ray 0 -- bw2 spontaneous 0 -- bw2MN ethyl methanesulfonate 0 -- bw2b X ray 5 -- bw2c spontaneous 0 -- bw30 spontaneous 0 -- bw33f heat-treatment 0 -- bw33g heat-treatment 0 -- bw37g spontaneous 0 -- bw38j 0 -- bw45a spontaneous 5 -- bw47j spontaneous natural population 0 -- bw48-366l natural population 0 -- bw49-1050 natural population 0 -- bw4 spontaneous 1 -- bw50b spontaneous 0 -- bw51i22 natural population 0 -- bw53l spontaneous 0 -- bw55k spontaneous 0 -- bw59 X ray 0 -- bw5 spontaneous 3 Yes bw609 0 -- bw69 X ray 0 -- bw6 spontaneous 0 Yes bw70 X ray 0 -- bw72 X ray 0 -- bw75 X ray 1 -- bw77 X ray 0 -- bw81 X ray 0 -- bw85f4 X ray 0 Yes bw979 spontaneous 0 -- bw99 0 -- bwAD spontaneous 0 -- bwAR ethyl methanesulfonate 0 -- bwB1.Y spontaneous 0 Yes bwB2.Y spontaneous 0 Yes bwB3 spontaneous 0 Yes bwB4 spontaneous 0 Yes bwB5 spontaneous 0 Yes bwC65 natural population 0 -- bwCB 2-chloroethyl methanesulfonate 0 -- bwD114 X ray 0 -- bwD2 X ray 0 -- bwD3 X ray 0 -- bwD amorph spontaneous 69 Yes bwDSu169 ethyl methanesulfonate 0 -- bwDa natural population 0 Yes bwDe2 natural population 0 Yes bwDe natural population 0 Yes bwDrv12 γ ray 0 -- bwDrv18 γ ray 0 -- bwG natural population 0 Yes bwIG281 natural population 0 Yes bwKN1 natural population 0 Yes bwKN2 natural population 0 Yes bwKN3 natural population 0 Yes bwKN4 natural population 0 Yes bwKN5 natural population 0 Yes bwKN6 natural population 0 Yes bwKN7 natural population 0 Yes bwM58 spontaneous 0 -- bwM590 0 -- bwMi59 spontaneous 0 -- bwN natural population 0 Yes bwR12 X ray 0 -- bwR14 X ray 0 -- bwR15 X ray 0 -- bwR18 X ray 0 -- bwR20 X ray 0 -- bwR25 X ray 0 -- bwR27 X ray 0 -- bwR32 X ray 0 -- bwR33 X ray 0 -- bwR35 X ray 0 -- bwR3 X ray 0 -- bwR40 X ray 0 -- bwR45 X ray 0 -- bwR47 X ray 0 -- bwR4 X ray 0 -- bwR50 X ray 0 -- bwR55 X ray 0 -- bwR56 X ray 0 -- bwR57 X ray 0 -- bwR58 X ray 0 -- bwR67 X ray 0 -- bwR68 X ray 0 -- bwR73 X ray 0 -- bwR79 X ray 0 -- bwRa 0 -- bwS natural population 0 Yes bwT50 natural population 0 Yes bwV1 X ray 37 Yes bwV29l <up>226</up>Ra α ray 0 -- bwV2 X ray 0 -- bwV30a X ray 0 -- bwV30k10 X ray 0 -- bwV30k12 X ray 0 -- bwV30k18 X ray 0 -- bwV30k1 X ray 0 -- bwV32g X ray 8 -- bwV34k X ray 3 -- bwV3 X ray 0 -- bwV40b X ray 0 -- bwV4 X ray 0 -- bwV54a γ ray 0 -- bwV54b γ ray neutrons 0 -- bwV54c neutrons 0 -- bwV57e X ray 0 -- bwV5 X ray 1 -- bwV6 X ray 0 -- bwV77k10(6) 0 -- bwV7 X ray 0 -- bwV8 X ray 0 -- bwVA 0 -- bwVD X ray 0 -- bwVDe1 X ray 2 -- bwVDe2 X ray 4 -- bwVDe3 X ray 1 -- bwVDe4 X ray 1 -- bwVI spontaneous X ray 0 -- bwa spontaneous 0 -- bwau spontaneous 0 --