A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Allele Dmel\GstS1k08805

General Information
SymbolDmel\GstS1k08805SpeciesD. melanogaster
NameFlyBase IDFBal0064316
Feature typealleleCreated / Updated2006-05-14/2006-05-14
Associated geneDmel\GstS1
Allele class
MutagenP-element activity
hide Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      Insertion of P{lacW} between bases 29 and 30 of the transcript, in the 5' UTR.
      (Singh et al., 2001)
      Assay mode
      Caused by insertion
      P{lacW}GstS1k08805
      (BDGP Project Members, 1994-1999, Tomkiel, 2001.12.6, Singh et al., 2001)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      lethal | recessive
      (BDGP Project Members, 1994-1999)
      hide Phenotype Manifest In
      hide Detailed Description
      Statement
      Reference
      GstS1k08805 mutants have no effect on climbing ability.
      (Whitworth et al., 2005)
      hide Interactions
      hide Phenotypic Class
      hideEnhancer of
      Statement
      Reference
      GstS1k08805/GstS1[+] is an enhancer of geotaxis behavior defective phenotype of park25
      (Whitworth et al., 2005)
      hideNOT Enhancer of
      Statement
      Reference
      GstS1k08805 is a non-enhancer of geotaxis behavior defective phenotype of park25
      (Whitworth et al., 2005)
      hide Phenotype Manifest In
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      The homozygous park25 mutant climbing defect is enhanced when heterozygous with GstS1k08805. GstS1k08805 mutants have no effect on climbing ability in heterozygous park25 mutants.
      (Whitworth et al., 2005)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 2 )
      Bloomington
      10803
      y1 w67c23; P{lacW}GstS1k08805/CyO
      Kyoto
      103363
      Df(1)w67c23, y1 ; P{lacW}GstS1k08805 / CyO
      hide Notes on Origin
      Discoverer
      I. Kiss.
      hide Comments
      This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).
       
      Complements: GstS104227. Complements: Sply05091. Complements: l(2)0625306253. Complements: l(2)k09303k09303. Complements: l(2)k09854k09854. Complements: l(2)k10815k10815. Complements: l(2)k11301k11301. Complements: l(2)k11405k11405.
      (BDGP Project Members, 1994-1999)
      hide Synonyms & Secondary IDs ( 5 )
      Reported As
      Symbol Synonym
      Gst2k08805
      (Singh et al., 2001, )
      GstS1K8805
      (Whitworth et al., 2005)
      GstS1k08805
       
      k08805
      (Ryder et al., 2004)
      l(2)k08805k08805
      (Tomkiel, 2001.12.6, BDGP Project Members, 1994-1999, )
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 5 )
        Research paper
        Whitworth et al., 2005, Proc. Natl. Acad. Sci. USA 102(22): 8024--8029
        Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. [FBrf0188281]
        Ryder et al., 2004, Genetics 167(2): 797--813
        The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. [FBrf0179424]
        Singh et al., 2001, Europ. J. Biochem. 268(10): 2912--2923
        Catalytic function of Drosophila melanogaster glutathione S-transferase DmGSTS1-1 (GST-2) in conjugation of lipid peroxidation end products. [FBrf0135754]
        Personal communication to FlyBase
        Tomkiel, 2001.12.6, Df(2R)P803-delta15.
        Df(2R)P803-delta15. [FBrf0141808]
        Computer file
        BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
        Berkeley Drosophila Genome Project. [FBrf0067338]