A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\Ubx130

General Information
SymbolDmel\Ubx130SpeciesD. melanogaster
NameFlyBase IDFBal0017400
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\Ubx
Allele classhypomorph
MutagenX ray
hide Nature of the Allele
Allele class
hypomorph
(Kauffman, 1981)
Mutagen
X ray
(Lindsley and Zimm, 1992)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      Breakpoint in Ubx.
      (Castelli-Gair and Garcia-Bellido, 1990)
      Assay mode
      Caused by aberration
      In(3LR)Ubx130
      (Bejarano and Busturia, 2004, Capdevila and Garcia-Bellido, 1981, Tiong et al., 1985, Tamkun et al., 1992)
      Carried on aberration
      TM2Z
      (FlyBase Curators, 2006-)
      TM2-vBa
      (FlyBase Curators, 2006-)
      TM2-ry
      (FlyBase Curators, 2006-)
      TM2-pp
      (FlyBase Curators, 2006-)
      TM2-l(3)E7-3-581
      (FlyBase Curators, 2006-)
      TM2-vFa
      (FlyBase Curators, 2006-)
      AM1
      (FlyBase Curators, 2006-, Lindsley and Zimm, 1992)
      TM2-P{Δ2-3}
      (FlyBase Curators, 2006-)
      TM2
      (FlyBase Curators, 2006-, Lindsley and Zimm, 1992)
      TM2-vAa
      (FlyBase Curators, 2006-)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      lethal | recessive
      (Lindsley and Zimm, 1992)
      visible | dominant
      (Kauffman, 1981)
      hide Phenotype Manifest In
      haltere
      (Shimojima et al., 2003, Kauffman, 1981, Laney and Biggin, 1996)
      dorsal metathoracic disc | anterior compartment (with Ubxbx-3)
      (de Navas et al., 2006)
      dorsal metathoracic disc | posterior compartment (with Ubxpbx-1)
      (de Navas et al., 2006)
      hide Detailed Description
      Statement
      Reference
      Heterozygotes have a slight transformation of haltere to wing at 29oC and 17oC. Ubx130/UbxCbx-1 flies show a temperature sensitive phenotype; flies grown at 29oC have a slight conversion of haltere to wing and strong transformation of wing to haltere, while those grown at 17oC have a strong haltere to wing transformation and a slight transformation of wing to haltere. The UbxCbx-1 transformation in the wing is generally reduced and the Ubx130 transformation in the haltere is generally enhanced in the transheterozygote, compared to heterozygous or homozygous UbxCbx-1 or Ubx130 flies respectively.
      (Kauffman, 1981)
      The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is increased in flies also containing a copy of Ubx130.
      (Capdevila and Garcia-Bellido, 1981)
      T(2;3)T1-19/Ubx130 flies show reduced viability and fecundity.
      (Puro, 1982)
      Transheterozygotes with UbxS1, UbxS2 and UbxS3 are viable.
      (Tiong et al., 1985)
      Flies carrying both RpII215Ubl and Ubx130 show a greater transformation of haltere to wing than flies carrying RpII215Ubl alone.
      (Mortin et al., 1985)
      Increases the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.
      (Castelli-Gair and Garcia-Bellido, 1990)
      Like Ubx1 as a dominant. RK1A.
      (Lindsley and Zimm, 1992)
      Ubx130 heterozygotes have normal halteres and nota.
      (Schwendemann and Lehmann, 2002)
      In Ubx130 mutant adults, halters are homogeneous in size and shape, being slightly larger than those in wild-type.
      (Shimojima et al., 2003)
      Ubx130 heterozygotes display slightly enlarged halteres compared to wild-type.
      (Faucheux et al., 2003)
      The anterior compartment is increased in size in Ubx[130]/Ubx[bx-3] haltere discs. The posterior compartment is increased in size in Ubx[130]/Ubx[pbx-1] haltere discs.
      (de Navas et al., 2006)
      hide Interactions
      hide Phenotypic Class
      hideEnhanced by
      Statement
      Reference
      Trl[+]/TrlR85, Ubx130 has visible | dominant phenotype, enhanceable by +/Df(2R)Δ18
      (Schwendemann and Lehmann, 2002)
      TrlR85, Ubx130 has visible phenotype, enhanceable by pho1
      (Bejarano and Busturia, 2004)
      TrlR85, Ubx130/Ubx[+] has visible | dominant phenotype, enhanceable by +/Df(2R)Δ18
      (Schwendemann and Lehmann, 2002)
      hideSuppressor of
      Statement
      Reference
      Ubx130/Ubx[+] is a suppressor | partially of visible phenotype of dppd5/dppd12
      (de Navas et al., 2006)
      hideOther
      Statement
      Reference
      Trl[+]/TrlR85, Ubx130 has visible | dominant phenotype
      (Schwendemann and Lehmann, 2002)
      TrlR85, Ubx130 has visible phenotype
      (Bejarano and Busturia, 2004)
      TrlR85, Ubx130 has visible | dominant phenotype
      (Schwendemann and Lehmann, 2002)
      hide Phenotype Manifest In
      hideEnhanced by
      Statement
      Reference
      Trl[+]/TrlR85, Ubx130 has haltere phenotype, enhanceable by +/Df(2R)Δ18
      (Schwendemann and Lehmann, 2002)
      Trl[+]/TrlR85, Ubx130 has mesothoracic tergum phenotype, enhanceable by +/Df(2R)Δ18
      (Schwendemann and Lehmann, 2002)
      Trl[+]/TrlR85, Ubx130 has wing | ectopic phenotype, enhanceable by +/Df(2R)Δ18
      (Schwendemann and Lehmann, 2002)
      Ubx130 has haltere phenotype, enhanceable by Df(3L)Aprt-21
      (Shimojima et al., 2003)
      Trl13C, Ubx130 has haltere phenotype, enhanceable by Df(3L)Aprt-21
      (Shimojima et al., 2003)
      Ubx130 has haltere phenotype, enhanceable by Trl13C
      (Shimojima et al., 2003)
      Ubx130 has phenotype, enhanceable by Trl13C
      (Farkas et al., 1994)
      TrlR85, Ubx130/Ubx[+] has haltere phenotype, enhanceable by +/Df(2R)Δ18
      (Schwendemann and Lehmann, 2002)
      TrlR85, Ubx130/Ubx[+] has mesothoracic tergum phenotype, enhanceable by +/Df(2R)Δ18
      (Schwendemann and Lehmann, 2002)
      TrlR85, Ubx130/Ubx[+] has wing | ectopic phenotype, enhanceable by +/Df(2R)Δ18
      (Schwendemann and Lehmann, 2002)
      hideSuppressed by
      Statement
      Reference
      Ubx130/Ubxbx-3 has dorsal metathoracic disc | anterior compartment phenotype, suppressible | partially by Scer\GAL4ptc-559.1/tkvScer\UAS.cLa
      (de Navas et al., 2006)
      hideSuppressor of
      Statement
      Reference
      Ubx130/Ubx[+] is a suppressor | partially of capitellum phenotype of dppd5/dppd12
      (de Navas et al., 2006)
      hideOther
      Statement
      Reference
      Trl[+]/TrlR85, Ubx130 has haltere phenotype
      (Schwendemann and Lehmann, 2002)
      Trl[+]/TrlR85, Ubx130 has mesothoracic tergum phenotype
      (Schwendemann and Lehmann, 2002)
      Trl[+]/TrlR85, Ubx130 has wing | ectopic phenotype
      (Schwendemann and Lehmann, 2002)
      +/Df(2R)Δ18, Ubx130 has haltere phenotype
      (Schwendemann and Lehmann, 2002)
      +/Df(2R)Δ18, Ubx130 has mesothoracic tergum phenotype
      (Schwendemann and Lehmann, 2002)
      +/Df(2R)Δ18, Ubx130 has wing | ectopic phenotype
      (Schwendemann and Lehmann, 2002)
      TrlR85, Ubx130 has haltere phenotype
      (Schwendemann and Lehmann, 2002, Schwendemann and Lehmann, 2002)
      TrlR85, Ubx130 has mesothoracic tergum phenotype
      (Schwendemann and Lehmann, 2002, Schwendemann and Lehmann, 2002)
      TrlR85, Ubx130 has wing | ectopic phenotype
      (Schwendemann and Lehmann, 2002)
      Df(3L)Aprt-21, Trl13C, Ubx130 has wing | ectopic phenotype
      (Shimojima et al., 2003, Shimojima et al., 2003)
      Trl13C, Ubx130 has haltere phenotype
      (Laney and Biggin, 1996, Laney and Biggin, 1996)
      TrlR85, Ubx130/Ubx[+] has haltere phenotype
      (Schwendemann and Lehmann, 2002)
      TrlR85, Ubx130/Ubx[+] has mesothoracic tergum phenotype
      (Schwendemann and Lehmann, 2002)
      TrlR85, Ubx130/Ubx[+] has wing | ectopic phenotype
      (Schwendemann and Lehmann, 2002)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      Heterozygotes have slightly enlarged halteres compared to wild type. Trl13C+/+Ubx130 double heterozygous flies have larger halteres than Ubx130 heterozygotes. Homeotic transformations include a low frequency of patches on the haltere and postnotum that develop like wing and notum tissues respectively.
      (Farkas et al., 1994)
      Flies doubly heterozygous for Ubx130 and Trl13C show larger halteres than Ubx130 heterozygotes alone, and with variable penetrance and expressivity show homeotic transformations of the haltere and postnotum. When zae(bx) is added to the doubly heterozygous combination the Ubx phenotype is enhanced.
      (Laney and Biggin, 1996)
      Ubx130/TrlR85 flies have a low penetrance of haltere to wing transformations and notal transformations. The penetrance of these phenotypes is significantly enhanced by heterozygosity for Df(2R)Δ18, even though the phenotypes are present at a very low penetrance (<0.5%) in Ubx130, Df(2R)Δ18 double heterozygotes.
      (Schwendemann and Lehmann, 2002)
      56% of Ubx130, Trl13C double heterozygotes have halteres that quite heterogeneous in size and larger than Ubx130 alone. 63% of Ubx130, Df(3L)Aprt-21 double heterozygotes have halteres that quite heterogeneous in size and larger than Ubx130 alone. 78% of Ubx130, Df(3L)Aprt-21, Trl13C triple heterozygotes have halteres that quite heterogeneous in size and larger than Ubx130 alone, also exhibiting a stronger phenotype than any two of the alleles used. The haltere becomes a wing -like structure with wing veins and hairs on the wing margin.
      (Shimojima et al., 2003)
      TrlR85/Ubx130; pho1 flies show an enhancement of the Ubx130 phenotype in 18% of flies.
      (Bejarano and Busturia, 2004)
      Double heterozygous lolalk02512 Ubx130 flies do not show significant increase in the expressivity of the Ubx phenotype. lolalk02512/+; Trl13C/Ubx130 flies display a higher frequency (18%) of strong haltere-to-wing transformations compared to Trl13C/Ubx130 siblings (6.3%). This increased transformation is often accompanied by a notal transformation.
      (Faucheux et al., 2003)
      The reduced size of the capitellum seen in dpp[d5]/dpp[d12] adults is partially suppressed by Ubx[130]/+.
      (de Navas et al., 2006)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 15 )
      Kyoto
      103308
      Df(3R)e-N19 / TM2, Ubx130 es
      101598
      Df(3R)ry-K / In(3LR)Ubx130, Ubx130
      101678
      l(3)DTS31 / TM2, Ubx130 es
      102015
      In(3LR)Ubx130, Ubx130 es ; T(3;4)e
      101621
      Df(3R)sbd26, st1 e1 / TM2, Ubx130 es
      101622
      Df(3R)sbd45, mwh1 e1 / TM2, Ubx130 es
      101588
      Df(3L)Ar11, red1 / TM2, emc2 pp Ubx130 es
      101589
      Df(3L)Ar12-1, red1 / TM2, emc2 pp Ubx130 es
      103298
      Df(3L)Ar14-8, red1 / TM2, emc2 pp Ubx130 es
      101894
      Dp(1;Y)BS / wa ; st1 tra1 / TM2, Ubx130 es
      Bloomington
      1699
      KgV red1 Sbsbd-1/Ubx130
      3461
      In(3R)iab7SGA, Abd-Biab7-SGA/Ubx130
      hide Notes on Origin
      Discoverer
      hide Comments
      Temperature-shift experiments show that the temperature sensitive period in Ubx130/UbxCbx-1 flies extends throughout embryonic and larval life.
      (Kauffman, 1981)
      The brm2 or trxE2 mutations greatly increase the frequency of haltere to wing transformation in double heterozygotes with Ubx130.
      (Tamkun et al., 1992)
      hide Synonyms & Secondary IDs ( 3 )
      Reported As
      Symbol Synonym
      Ubx130
      (Camprodon and Castelli-Gair, 1994)
      Ubx130
      (de Navas et al., 2006)
      unnamed
      (Capdevila and Garcia-Bellido, 1981)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 28 )
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        hide Recent research papers ( 1 )
        de Navas et al., 2006, Development 133(22): 4495--4506
        The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway. [FBrf0194425]
        Show all research papers ...