A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\b1

General Information
SymbolDmel\b1SpeciesD. melanogaster
NameFlyBase IDFBal0000858
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\b
Allele class
Mutagenspontaneous
hide Nature of the Allele
Allele class
Mutagen
spontaneous
(Ashburner et al., 1999.10.12)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      There is an amino acid replacement in a conserved residue (Y348H, nucleotide substitution T1042C) compared to the wild-type sequence, and, in addition, upstream of the amino acid replacement, four bases (ATCC) have been replaced by an eight base pair insertion (TACCTACC) at nucleotide position +530, resulting in a frameshift that is expected to produce a truncated, enzymatically-inactive protein.
      (Phillips et al., 2005)
      Assay mode
      Carried on aberration
      Df(2L)k14608-mr4
      (Roote, 2000.6.13)
      Df(2L)PZ05271-mr15
      (Roote, 2000.6.13)
      Df(2L)PZ05271-mr45
      (Roote, 2000.6.13)
      Df(2L)B11
      (Hardy, 2005.6.1)
      Df(2L)PZ07130-mr9
      (Roote, 2000.6.13)
      Df(2L)k07245-mr32
      (Roote, 2000.6.13)
      F(2L)D13
       
      Dp(2;2)Cam8a
      (Roote, 2004.6.24)
      Df(2L)PZ06430-mr2
      (Roote, 2000.6.13)
      Df(2L)k14608-mr6
      (Roote, 2000.6.13)
      Df(2L)k14608-mr27
      (Roote, 2000.6.13)
      Df(2L)k07245-mr11
      (Roote, 2000.6.13)
      F(2L)F14
       
      Df(2L)k14608-mr15
      (Roote, 2000.6.13)
      Dp(2;2)Cam8
      (Roote, 2004.6.24)
      Df(2L)k09033-mr19
      (Roote, 2000.6.13)
      C(2L)RM-C3
      (Gubb et al., 1991)
      Df(2L)k07245-mr2
      (Roote, 2000.6.13)
      Df(2L)PZ06430-mr11
      (Roote, 2000.6.13)
      Dp(2;2)Cam5
      (Roote, 2004.6.24)
      Dp(2;2)Cam10
      (Roote, 2004.6.24)
      Df(2L)I131
      (Hardy, 2005.6.1)
      C(2R)RM-VK2
      (Hilliker and Holm, 1975)
      Df(2L)PZ07130-mr1
      (Roote, 2000.6.13)
      Df(2L)A33
      (Hardy, 2005.6.1)
      Df(2L)PZ06430-mr14
      (Roote, 2000.6.13)
      Df(2L)k09033-mr9
      (Roote, 2000.6.13)
      C(2)EN-vNa
      (Novitski et al., 1981)
      C(2L)TY1
      (Hilliker and Holm, 1975)
      C(2L)RM-P1
       
      C(2L)RM-LS1
       
      CyO-vAa
      (FlyBase Curators, 2006-, Lindsley and Zimm, 1992)
      Df(2L)k14608-mr16
      (Roote, 2000.6.13)
      Df(2L)k05007-mr19
      (Roote, 2000.6.13)
      Df(2L)A92
      (Hardy, 2005.6.1)
      Dp(2;2)Cam16
      (Roote, 2004.6.24)
      In(2L)Cy
      (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
      Df(2L)k14608-mr29
      (Roote, 2000.6.13)
      F(2L)112
       
      Df(2L)k07245-mr31
      (Roote, 2000.6.13)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      viable
      (Phillips et al., 2005)
      body color defective
       
      visual behavior defective
      (Phillips et al., 2005)
      hide Phenotype Manifest In
      hide Detailed Description
      Statement
      Reference
      Body colour: black. RK1 in aged flies.
       
      Levels of β-alanine transaminase activity are elevated compared to wild-type in newly emerged adults up to five hours postemergence. Levels of β-alanine transaminase activity are higher in su(b)6 ; b1 double mutant flies than in su(b)6 single mutant flies. Levels of β-alanine transaminase activity in su(b)6; b1 double mutant flies are lower than wild-type levels.
      (Weber et al., 1992)
      When unpigmented b1 pharate adult tissue is incubated with dopamine in vitro, the extent of inducible pigmentation of body cuticle, hairs and bristle sockets resembles that of wild-type, while pigmentation of the bristle shafts is significantly reduced.
      (Walter et al., 1996)
      b1 flies have a normal electroretinogram. b1 flies show no difference in walking speed or walking distance compared to wild-type flies when assayed in Buridan's paradigm. However, the number of walks initiated by b1 flies is significantly different from that of wild-type flies and fixation behaviour is defective in b1 flies in this assay.
      (Phillips et al., 2005)
      hide Interactions
      hide Phenotypic Class
      hideEnhancer of
      Statement
      Reference
      b1 is an enhancer of body color defective phenotype of Sk1
      (Lindsley and Zimm, 1992)
      hideNOT Suppressor of
      Statement
      Reference
      b1 is a non-suppressor of neurophysiology defective phenotype of e11
      (Phillips et al., 2005)
      hide Phenotype Manifest In
      hideNOT suppressed by
      Statement
      Reference
      b1 has phenotype, non-suppressible by su(Hw)2
      (Lindsley and Grell, 1968)
      hideEnhancer of
      Statement
      Reference
      b1 is an enhancer of scutellum phenotype of Sk1
      (Lindsley and Zimm, 1992)
      hideNOT Suppressor of
      Statement
      Reference
      b1 is a non-suppressor of retina phenotype of e11
      (Phillips et al., 2005)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      The electroretinogram phenotype of b1 ; e11 double mutant flies is identical to that of e11 single mutants.
      (Phillips et al., 2005)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 549 )
      Bloomington
      227
      b1
      232
      b1 sf1
      3980
      b1 vg1
      4193
      b1 gp1
      6120
      Df(2L)J17, b1/CyO
      8502
      b1; ome1
      Kyoto
      105800
      b1
      101295
      b1 c1
      107540
      b1 vg1
      101299
      b1 Adhn1
      107304
      b1 tyr11
      108620
      Df(2L)J17, b1/CyO
      hide Notes on Origin
      Discoverer
      Morgan, 1910.
      hide Synonyms & Secondary IDs ( 3 )
      Reported As
      Symbol Synonym
      b
      (Weber et al., 1992, Novitski et al., 1981)
      b1
       
      unnamed
      (Roote, 2004.6.24)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 18 )
        Research paper
        Phillips et al., 2005, Gene 351: 131--142
        The Drosophila black enigma: the molecular and behavioural characterization of the black1 mutant allele. [FBrf0187584]
        Baier et al., 2002, J. exp. Biol. 205(9): 1233--1240
        Drosophila as a new model organism for the neurobiology of aggression? [FBrf0147123]
        Walter et al., 1996, Arch. Insect Biochem. Physiol. 31(2): 219--233
        Catecholamine metabolism and in vitro induction of premature cuticle melanization in wild type and pigmentation mutants of Drosophila melanogaster. [FBrf0086102]
        Weber et al., 1992, Biochim. biophys. Acta 1115: 181--186
        -alanine transaminase activity in black and suppressor of black mutations of Drosophila melanogaster. [FBrf0055466]
        Gubb et al., 1991, D. I. N. 2:
        Genetic Notes: Autosynaptics made easy. [FBrf0053501]
        Novitski et al., 1981, Genetics 98(2): 257--273
        The entire compound autosomes of Drosophila melanogaster. [FBrf0036510]
        Hilliker and Holm, 1975, Genetics 81: 705--721
        Genetic analysis of the proximal region of chromosome 2 of Drosophila melanogaster. [FBrf0027524]
        Bridges and Morgan, 1919, Publs Carnegie Instn 278: 123--304
        Contributions to the genetics of Drosophila melanogaster. [FBrf0000979]
        Personal communication to FlyBase
        Hardy, 2005.6.1, Goodman deletions.
        Goodman deletions. [FBrf0188628]
        Roote, 2004.6.24, Cam Dps.
        Cam Dps. [FBrf0178882]
        Roote, 2000.6.13, New P derivatives.
        New P derivatives. [FBrf0129261]
        Ashburner et al., 1999.10.12, Adh.
        Adh. [FBrf0112153]
        Abstract
        Phillips et al., 2001, Bellen, Taylor, 2001: 198
        A neurological role for the product of the black gene? [FBrf0144637]
        FlyBase analysis
        FlyBase Curators, 2006-, Balancer summary information.
        Balancer summary information. [FBrf0189689]
        Book
        Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
        The Genome of Drosophila melanogaster. [FBrf0066905]
        Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp
        Genetic variations of Drosophila melanogaster. [FBrf0020044]
        Bridges and Brehme, 1944, Publs Carnegie Instn 552: vii + 257pp
        The mutants of Drosophila melanogaster. [FBrf0006100]
        Stock list
        The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Russia, 1997, D. I. S. 80: 109--130
        Stock list. [FBrf0098381]