Aberration Dmel\In(2LR)Px⁴

General Information
Symbol	Dmel\In(2LR)Px⁴	Species	D. melanogaster
Name	Inversion (2LR) Plexate	FlyBase ID	FBab0004789
Feature type	chromosomal_inversion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data
Sequence coordinates
Deleted segment
Duplicated segment
Computed Breakpoints include
Breakpoints Inherited
Nature of the Aberration
Cytological Order	2Lt - 22A3 \| 60B - 58B1 \| 42A3 - 58A4 \| 42A2 - 21D1 \| 60D2 - 2Rt
Progenitor	In(2LR)SM1 In(2LR)bw^V1
Mutagen	recombination
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Inverted for 60B8-60B10;60D1 (Wang et al., 1997) Deficient for 60B-60C;60D1-60D2 (Peng and Mount, 1990)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Zfrp8 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Dat (Brodbeck et al., 1998, Shaw et al., 2000) spag (BDGP Project Members, 1994-1999, Spradling et al., 1999) bs (Kimble et al., 1990, BDGP Project Members, 1994-1999, Guillemin et al., 1996, Montagne et al., 1996, Prout et al., 1997, Spradling et al., 1999) slbo (Montell et al., 1992) Mov34 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Nop60B (BDGP Project Members, 1994-1999, Phillips et al., 1998, Giordano et al., 1999, Spradling et al., 1999, Kauffman et al., 2003) sp (Peng and Mount, 1990) l(2)60Cd (Kimble et al., 1990) Pin l(2)60Cb (Kimble et al., 1990) l(2)60Ca (Kimble et al., 1990) God (Ruden and Jaeckle, 1995) Px l(2)60Cc (Kimble et al., 1990)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	ken (BDGP Project Members, 1994-1999) mr (Reed, 1992) sei (Wang et al., 1997) eIF-5A (BDGP Project Members, 1994-1999, Spradling et al., 1999) tsr (BDGP Project Members, 1994-1999) Chi (BDGP Project Members, 1994-1999) Thiolase (BDGP Project Members, 1994-1999) βTub60D (Kimble et al., 1990) gek (BDGP Project Members, 1994-1999, Spradling et al., 1999) CG3511 (Edgar et al., 2005) Nurf-38 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Dll (BDGP Project Members, 1994-1999, Spradling et al., 1999) Peb (Ludwig et al., 1991) zip (Gotwals and Fristrom, 1991) Adk2-60B (BDGP Project Members, 1994-1999) l(2)04012a (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)05006 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k10502 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k06608b (BDGP Project Members, 1994-1999) l(2)60Db (Kimble et al., 1990) l(2)60De (Kimble et al., 1990) l(2)60Dg (Kimble et al., 1990) milou (Galloni and Edgar, 1999) l(2)60Dc (Kimble et al., 1990) l(2)60Df (Kimble et al., 1990) E(w^a) (Peng and Mount, 1990) l(2)60Dd (Kimble et al., 1990) l(2)60Da (Kimble et al., 1990) snama (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Molecular Data
Genes Duplicated
Complementation Data
Completely duplicated	S
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Heterozygotes have a blistered wing and ectopic vein phenotype. (Firth et al., 2000) Heterozygotes with T(2;3)God¹ are inviable. (Ruden and Jaeckle, 1995) Homozygotes die at the beginning of the first larval instar stage because the larvae cannot exit from the chorion. The larvae are deformed with stunted growth. The sclerotised mouthparts and denticle belts develop normally. (Brodbeck et al., 1998) Intermediate second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1: malformed phenotype penetrance 25-75%. (Halsell and Kiehart, 1998) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Progeny of the genotype zip/Df(zip) exhibit the mlf phenotype (malformed syndrome), wing malformations and leg defects, at a penetrance of 14--35%. (Gotwals and Fristrom, 1991) Shows a haploinsufficient ectopic wing vein phenotype. (Montagne et al., 1996) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) The tracheal phenotypes previously reported for this deficiency in FBrf0051997 and FBrf0072461, where the primary branches are disrupted and discontinuous, are due to the deletion of a gene other than bs, or more than one gene in the region. (Guillemin et al., 1996) Wing venation phenotype like Df(2R)Px1. Thickening of L5 at posterior crossvein produces a vesicle, as in bs. More extreme in female. homozygous lethal
Position Effect Variegation Data

Stocks ( 3 )
Bloomington	1473 In(2LR)Px⁴, dp^ov1 b¹/CyO
Kyoto	106331 In(2LR)Px⁴, dp^ov1 b¹/CyO 101450 In(2LR)Px⁴, dp^ov1 b¹ / In(2LR)Gla, wg^Gla-1
Notes on Origin
Discoverer	Thompson, June 1956, 1957.
	A recurrent product of recombination in region 33F-40F between In(2LR)21C8-D1;60D1-2 from In(2LR)bw^V1 [In(2LR)21C8-D1;60D1-2 + In(2LR)40F;59D4-E1] and In(2LR)22A3-B1;60B-C from SM1 [In(2L)Cy = In(2L)22D1-2;33F5-34A1 + In(2LR)22A3-B1;60B-C + In(2R)Cy = In(2R)42A2-3;58A4-B1].
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	"Deletes or disrupts sp" was stated as tentative. The reciprocal recombinant is In(2LR)S^56f.
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	BL-1473 (Edgar et al., 2005) Df(2LR)Px4 (Kauffman et al., 2003) Df(2R)Px1 (Shaw et al., 2000) Df(2R)Px4 (Krupp et al., 2005, Firth et al., 2000, Giordano et al., 1999, Nicholls and Gelbart, 1998, Matunis et al., 1997, Prout et al., 1997, Guillemin et al., 1996, Bilder and Scott, 1995, Fristrom et al., 1994, Crest et al., 2007) Df(2R)Px4,Dp(2L) (Tran and Berg, 2003) Df(2R)Px[4] (Firth et al., 2000) Df(2R)Px⁴ (Abrell et al., 2000, Galloni and Edgar, 1999, Phillips et al., 1998, Wang et al., 1997, Montagne et al., 1996, Ruden and Jaeckle, 1995, Ludwig et al., 1991, Brodbeck et al., 1998) Dp(2;2)S^56f In(2LR)Px4 (Presgraves, 2003, Shamloula et al., 2002, Lee et al., 2001, ) In(2LR)Px⁴ In(2R)Px⁴ (Peng and Mount, 1990) Px⁴ (Thompson, 1963)
Name Synonym	Inversion (2LR) Plexate
Secondary FlyBase IDs
	FBab0004790 FBab0003501
References ( 37 )

Generate a list of	All references relating to this aberration ( 37 )

List References by type	Research paper ( 34 ) Computer file ( 1 ) Thesis ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Show all research papers ...

Aberration Dmel\In(2LR)Px4

Aberration Dmel\In(2LR)Px⁴