Aberration Dmel\Df(3R)Dl-M2

General Information
Symbol	Dmel\Df(3R)Dl-M2	Species	D. melanogaster
Name	Deficiency (3R) Delta	FlyBase ID	FBab0002552
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << l(3)91Fa << Dl << bk2
Sequence coordinates
Deleted segment	91C7--92A2
Duplicated segment
Computed Breakpoints include	91C7--D1;[>92A2]
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Alton et al., 1988, Hukriede and Fleming, 1997)
Breakpoints	91C7-91D1;92A1 (Alton et al., 1988) 91C7-97D1;92A1 (Hukriede and Fleming, 1997)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Alton et al., 1989)
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0048201) Left limit of break 2 from inclusion of Dl (FBrf0048201)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	Dl (Alton et al., 1988) l(3)91Fb (Alton et al., 1988) l(3)91Ff (Alton et al., 1988) l(3)91Fc (Alton et al., 1988) l(3)91Fe (Alton et al., 1988) l(3)92Aa (Alton et al., 1988) l(3)91Fa (Alton et al., 1988)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Heterozygotes with Ser^Bd-3 are viable and exhibit a severe wing phenotype. (Hukriede and Fleming, 1997) Potentiates the effects of dsh^hs.PA in the wing. (Axelrod et al., 1996)
Position Effect Variegation Data

Stocks ( 2 )
Kyoto	108321 Df(3R)Dl-M2/TM6C, Sb¹
Bloomington	5597 Df(3R)Dl-M2/TM6C, Sb¹ Tb¹
Notes on Origin
Discoverer	Myers, Gelbart.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(3R)Dl^M2 (Jacobsen et al., 1998, Muskavitch, 1994, Kopczynski et al., 1988, Bender et al., 1993, Kooh et al., 1993, Alton et al., 1988, Alton et al., 1989) Df(3R)Dl-M2 (Liao et al., 2006) Dl^M2 (Zhang et al., 1999, Hukriede and Fleming, 1997)
Name Synonym	Deficiency (3R) Delta
Secondary FlyBase IDs

References ( 16 )
Research paper	Liao et al., 2006, Genetics 174(1): 525--533 An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. [FBrf0192853] Bogwitz et al., 2005, Proc. Natl. Acad. Sci. USA 102(36): 12807--12812 Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. [FBrf0188252] Ryder et al., 2004, Genetics 167(2): 797--813 The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. [FBrf0179424] Zhang et al., 1999, Genetics 151(2): 697--711 A genetic screen for modifiers of Drosophila Src42A identifies mutations in egfr, rolled and a novel signaling gene. [FBrf0107534] Jacobsen et al., 1998, Development 125(22): 4531--4540 Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila. [FBrf0105854] Hukriede and Fleming, 1997, Genetics 145(2): 359--374 Beaded of Goldschmidt, an antimorphic allele of Serrate, encodes a protein lacking transmembrane and intracellular domains. [FBrf0092564] Axelrod et al., 1996, Science 271(5257): 1826--1832 Interaction between Wingless and Notch signaling pathways mediated by Dishevelled. [FBrf0086318] Muskavitch, 1994, Dev. Biol. 166(2): 415--430 Delta-Notch signaling and Drosophila cell fate choice. [FBrf0079071] Bender et al., 1993, Genetics 133(4): 967--978 Complex function and expression of Delta during Drosophila oogenesis. [FBrf0058578] Kooh et al., 1993, Development 117(2): 493--507 Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. [FBrf0058087] Alton et al., 1989, Dev. Genet. 10: 261--272 Molecular genetics of Delta, a locus required for ectodermal differentiation in Drosophila. [FBrf0049525] Alton et al., 1988, Genetics 118: 235--245 Cytogenetic definition and morphogenetic analysis of Delta, a gene affecting neurogenesis in Drosophila melanogaster. [FBrf0048201] Kopczynski et al., 1988, Genes Dev. 2(21): 1723--1735 Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates. [FBrf0048107]
Personal communication to FlyBase	Ryder and Roote, 2004.11.10, DrosDel deletions confirmed by PCR and genetic tests. DrosDel deletions confirmed by PCR and genetic tests. [FBrf0179888]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]