Aberration Dmel\Df(2L)E110

General Information
Symbol	Dmel\Df(2L)E110	Species	D. melanogaster
Name		FlyBase ID	FBab0001456
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << E(var)26A << bk2
Sequence coordinates
Deleted segment	25F3--26D11
Duplicated segment
Computed Breakpoints include	25F3-26A1;26D3-26D11
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	P-element activity PM hybrid dysgenesis (Locke et al., 1988)
Class of aberration (relative to progenitor)	chromosomal_deletion (Locke et al., 1988)
Breakpoints	25F3-26A1;26D3-26D11 (Locke et al., 1988)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0048198)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	eIF-4a (BDGP Project Members, 1994-1999, Spradling et al., 1999, Li et al., 2005) slmo (Carhan et al., 2004) lid (Gildea et al., 2000) l(2)k06502 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k06107 (BDGP Project Members, 1994-1999) E(var)26A (Locke et al., 1988)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	cype (BDGP Project Members, 1994-1999, Spradling et al., 1999) Lam (BDGP Project Members, 1994-1999, Spradling et al., 1999) Kr-h1 (BDGP Project Members, 1994-1999, Spradling et al., 1999) Gef26 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k09923 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k04909b (BDGP Project Members, 1994-1999) l(2)k03201 (BDGP Project Members, 1994-1999) S(CycE^JP)2.8 (Brumby et al., 2004) l(2)00455b (BDGP Project Members, 1994-1999) l(2)k07502b (BDGP Project Members, 1994-1999, Spradling et al., 1999) Sec61α (Beaton, 1997.3.4)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Enhance mottling in w^m4. (Tartof et al., 1989) Enhances position-effect variegation of In(1)w^m4. Recessive lethal. Heterozygosity for Df(2L)E110 results in 2.6% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Homozygous lethal. (Locke et al., 1988) The Df(2L)E110 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,w^var}2Lt insertion). (Mason et al., 2004) Wild-type clones made in the ovaries of a mutant female, are significantly larger than clones of heterozygous mutant cells. This size difference is greater in clones initiated at 48 hours after egg laying (AEL) than 2 hours AEL. (Extavour and Garcia-Bellido, 2001)
Position Effect Variegation Data

Stocks ( 2 )
Bloomington	490 In(1)w^m4; Df(2L)E110/CyO
Kyoto	108906 In(1)w^m4; Df(2L)E110/CyO
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Df(2L)E110 (Secombe et al., 2007, Schimmelpfeng et al., 2006) E110 (Locke et al., 1988, Tartof et al., 1989)
Name Synonym
Secondary FlyBase IDs

References ( 21 )

Generate a list of	All references relating to this aberration ( 21 )

List References by type	Research paper ( 17 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Computer file ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Secombe et al., 2007, Genes Dev. 21(5): 537--551 The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. [FBrf0193047] Schimmelpfeng et al., 2006, Mech. Dev. 123(6): 487--499 Mummy encodes an UDP-N-acetylglucosamine-dipohosphorylase and is required during Drosophila dorsal closure and nervous system development. [FBrf0195253] Show all research papers ...